Method for inducing a TRIF-bias

Method for inducing a TRIF-bias

The use of a selected aminoalkyl glusoaminide 4-phosphate (AGP) CRX-547 to induce a TRIF biased response in a human system, which results in reduced levels of MyD88-dependent cytokines relative to the MyD88-dependent cytokines induced by its diastereomer AGP CRX-527.

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Hauptverfasser: JOHNSON DAVID A, HUTTON MELINDA M, EVANS JAY T, MINNS LAURIE A, BOWEN WILLIAM S
Format: Patent
Sprache:eng
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator JOHNSON DAVID A
HUTTON MELINDA M
EVANS JAY T
MINNS LAURIE A
BOWEN WILLIAM S
description The use of a selected aminoalkyl glusoaminide 4-phosphate (AGP) CRX-547 to induce a TRIF biased response in a human system, which results in reduced levels of MyD88-dependent cytokines relative to the MyD88-dependent cytokines induced by its diastereomer AGP CRX-527.
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subjects HUMAN NECESSITIES
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MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title Method for inducing a TRIF-bias
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