Process for preparing A 2-substituted benzofuran-3-yl borate ester

The invention relates to a process for preparing a stable 2-substituted benzofuran-3-yl borate ester corresponding to the formula: said process comprising contacting 3-bromo-2-substituted-benzofuran corresponding to the formula: with an C1-4 alkyllithium at a temperature less than -60° C. to form 3-...

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Hauptverfasser: IVERSON CARL N, VOSEJPKA PAUL C, FRAZIER KEVIN A, BOONE HAROLD W
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The invention relates to a process for preparing a stable 2-substituted benzofuran-3-yl borate ester corresponding to the formula: said process comprising contacting 3-bromo-2-substituted-benzofuran corresponding to the formula: with an C1-4 alkyllithium at a temperature less than -60° C. to form 3-lithio-2-substititued-benzofuran, contacting the 3-lithio-2-substituted- benzofuran at a temperature less than -60° C. with an borate ester corresponding to the formula: and recovering the resulting borate ester product, wherein, RW' is C1-4 alkyl; Rx is C1-10 hydrocarbyl or halohydrocarbyl; and RY independently each occurrence is C1-10 hydrocarbyl, halohydrocarbyl or trialkylsilylhydrocarbyl or 2 RY groups together are a divalent hydrocarbylene of up to 20 carbons.