Catalyzed carbonylation in the synthesis of angiotensin II antagonists

Catalyzed carbonylation in the synthesis of angiotensin II antagonists

One embodiment disclosed in the invention is the efficient synthesis of halogenated biaryl starting material via Grignard chemistry and the use thereof. Another embodiment of the invention is the reaction of catalyzed carbonylation of the 3'-(2'-halo-biphenyl-4-ylmethyl)-1,7'-dimethyl...

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Hauptverfasser: COPAR ANTON, PREMRL ANDREJ, CASAR ZDENKO, CLUZEAU JEROME
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Sprache:eng
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator COPAR ANTON
PREMRL ANDREJ
CASAR ZDENKO
CLUZEAU JEROME
description One embodiment disclosed in the invention is the efficient synthesis of halogenated biaryl starting material via Grignard chemistry and the use thereof. Another embodiment of the invention is the reaction of catalyzed carbonylation of the 3'-(2'-halo-biphenyl-4-ylmethyl)-1,7'-dimethyl-2'-propyl-1H,3'H-[2,5']bibenzoimidazolyl (TLMH) using either gaseous carbon monoxide in a solvent mixture containing water; or formic acid salts optionally together with acetic acid in anhydrous solvent.
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HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title Catalyzed carbonylation in the synthesis of angiotensin II antagonists
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