Inhibitors of dihydrofolate reductase with antibacterial antiprotozoal, antifungal and anticancer properties

The compositions and methods described herein discloses the design, synthesis and testing of compounds that act as inhibitors of DHFR. The basic scaffold of these inhibitors includes a 2,4-diaminopyrimidine ring with a propargyl linker to another substituted aryl, bicyclo or heteroaryl ring. These D...

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