Protease inhibitors

The present invention provides HIV protease inhibitors of formulas I, IA, IB, Ib or II, or pharmaceutically acceptable salts thereof, wherein R2 may be, for example, 2-pyridyl-CH2-, 3 -pyridyl-CH2-, 4-pyridyl-CH2-, a sulfonyl group as described in the formulas herein including benzenesulfonyl or thi...

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Hauptverfasser:	PERRON VALERIE, LAVALLEE JEAN-FRANCOIS, LEBERRE NICOLAS, PANCHAL CHANDRA, STRANIX BRENT RICHARD, MILOT GUY, HERBART DOMINIK
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY METALLURGY ORGANIC CHEMISTRY
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creator	PERRON VALERIE LAVALLEE JEAN-FRANCOIS LEBERRE NICOLAS PANCHAL CHANDRA STRANIX BRENT RICHARD MILOT GUY HERBART DOMINIK
description	The present invention provides HIV protease inhibitors of formulas I, IA, IB, Ib or II, or pharmaceutically acceptable salts thereof, wherein R2 may be, for example, 2-pyridyl-CH2-, 3 -pyridyl-CH2-, 4-pyridyl-CH2-, a sulfonyl group as described in the formulas herein including benzenesulfonyl or thiophenesulfonyl groups, R2a-CO-, R2a being selected from the group consisting of piperonyl, 2-pyrazinyl (unsubstituted or substituted with H, or an alkyl of 1 to 4 carbon atoms) or a picolylamine group as described herein, wherein R3 may be, for example, a phenyl group or diphenylmethyl group as described herein, and wherein Cx may be, for example, COOH, CONR5R6, CH2OH or CH2OR7.
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CHEMISTRY ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2013</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20130402&DB=EPODOC&CC=US&NR=8410300B2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20130402&DB=EPODOC&CC=US&NR=8410300B2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>PERRON VALERIE</creatorcontrib><creatorcontrib>LAVALLEE JEAN-FRANCOIS</creatorcontrib><creatorcontrib>LEBERRE NICOLAS</creatorcontrib><creatorcontrib>PANCHAL CHANDRA</creatorcontrib><creatorcontrib>STRANIX BRENT RICHARD</creatorcontrib><creatorcontrib>MILOT GUY</creatorcontrib><creatorcontrib>HERBART DOMINIK</creatorcontrib><title>Protease inhibitors</title><description>The present invention provides HIV protease inhibitors of formulas I, IA, IB, Ib or II, or pharmaceutically acceptable salts thereof, wherein R2 may be, for example, 2-pyridyl-CH2-, 3 -pyridyl-CH2-, 4-pyridyl-CH2-, a sulfonyl group as described in the formulas herein including benzenesulfonyl or thiophenesulfonyl groups, R2a-CO-, R2a being selected from the group consisting of piperonyl, 2-pyrazinyl (unsubstituted or substituted with H, or an alkyl of 1 to 4 carbon atoms) or a picolylamine group as described herein, wherein R3 may be, for example, a phenyl group or diphenylmethyl group as described herein, and wherein Cx may be, for example, COOH, CONR5R6, CH2OH or CH2OR7.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2013</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZBAOKMovSU0sTlXIzMvITMosyS8q5mFgTUvMKU7lhdLcDApuriHOHrqpBfnxqcUFicmpeakl8aHBFiaGBsYGBk5GxkQoAQD-MCBK</recordid><startdate>20130402</startdate><enddate>20130402</enddate><creator>PERRON VALERIE</creator><creator>LAVALLEE JEAN-FRANCOIS</creator><creator>LEBERRE NICOLAS</creator><creator>PANCHAL CHANDRA</creator><creator>STRANIX BRENT RICHARD</creator><creator>MILOT GUY</creator><creator>HERBART DOMINIK</creator><scope>EVB</scope></search><sort><creationdate>20130402</creationdate><title>Protease inhibitors</title><author>PERRON VALERIE ; LAVALLEE JEAN-FRANCOIS ; LEBERRE NICOLAS ; PANCHAL CHANDRA ; STRANIX BRENT RICHARD ; MILOT GUY ; HERBART DOMINIK</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US8410300B23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2013</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>PERRON VALERIE</creatorcontrib><creatorcontrib>LAVALLEE JEAN-FRANCOIS</creatorcontrib><creatorcontrib>LEBERRE NICOLAS</creatorcontrib><creatorcontrib>PANCHAL CHANDRA</creatorcontrib><creatorcontrib>STRANIX BRENT RICHARD</creatorcontrib><creatorcontrib>MILOT GUY</creatorcontrib><creatorcontrib>HERBART DOMINIK</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>PERRON VALERIE</au><au>LAVALLEE JEAN-FRANCOIS</au><au>LEBERRE NICOLAS</au><au>PANCHAL CHANDRA</au><au>STRANIX BRENT RICHARD</au><au>MILOT GUY</au><au>HERBART DOMINIK</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Protease inhibitors</title><date>2013-04-02</date><risdate>2013</risdate><abstract>The present invention provides HIV protease inhibitors of formulas I, IA, IB, Ib or II, or pharmaceutically acceptable salts thereof, wherein R2 may be, for example, 2-pyridyl-CH2-, 3 -pyridyl-CH2-, 4-pyridyl-CH2-, a sulfonyl group as described in the formulas herein including benzenesulfonyl or thiophenesulfonyl groups, R2a-CO-, R2a being selected from the group consisting of piperonyl, 2-pyrazinyl (unsubstituted or substituted with H, or an alkyl of 1 to 4 carbon atoms) or a picolylamine group as described herein, wherein R3 may be, for example, a phenyl group or diphenylmethyl group as described herein, and wherein Cx may be, for example, COOH, CONR5R6, CH2OH or CH2OR7.</abstract><oa>free_for_read</oa></addata></record>
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subjects	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY METALLURGY ORGANIC CHEMISTRY
title	Protease inhibitors
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