Protease inhibitors

The present invention provides HIV protease inhibitors of formulas I, IA, IB, Ib or II, or pharmaceutically acceptable salts thereof, wherein R2 may be, for example, 2-pyridyl-CH2-, 3 -pyridyl-CH2-, 4-pyridyl-CH2-, a sulfonyl group as described in the formulas herein including benzenesulfonyl or thi...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: PERRON VALERIE, LAVALLEE JEAN-FRANCOIS, LEBERRE NICOLAS, PANCHAL CHANDRA, STRANIX BRENT RICHARD, MILOT GUY, HERBART DOMINIK
Format: Patent
Sprache:eng
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Zusammenfassung:The present invention provides HIV protease inhibitors of formulas I, IA, IB, Ib or II, or pharmaceutically acceptable salts thereof, wherein R2 may be, for example, 2-pyridyl-CH2-, 3 -pyridyl-CH2-, 4-pyridyl-CH2-, a sulfonyl group as described in the formulas herein including benzenesulfonyl or thiophenesulfonyl groups, R2a-CO-, R2a being selected from the group consisting of piperonyl, 2-pyrazinyl (unsubstituted or substituted with H, or an alkyl of 1 to 4 carbon atoms) or a picolylamine group as described herein, wherein R3 may be, for example, a phenyl group or diphenylmethyl group as described herein, and wherein Cx may be, for example, COOH, CONR5R6, CH2OH or CH2OR7.