Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
The present invention provides compounds of Formula (I) including tautomers, resolved enantiomers, resolved diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as Akt protein kinase inhibitor...
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| creator | MITCHELL IAN S HENTEMANN MARTIN F SAMMOND DOUGLAS M XU RUI BENCSIK JOSEF R WALLACE ELI M FONG KIN CHIU BANKA ANNA L TANG TONY BLAKE JAMES F |
| description | The present invention provides compounds of Formula (I) including tautomers, resolved enantiomers, resolved diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as Akt protein kinase inhibitors and for the treatment of Akt-mediated diseases, for example, hyperproliferative diseases such as cancer. |
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Also provided are methods of using the compounds of this invention as Akt protein kinase inhibitors and for the treatment of Akt-mediated diseases, for example, hyperproliferative diseases such as cancer.</description><language>eng</language><subject>AGRICULTURE ; ANIMAL HUSBANDRY ; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES ; CHEMISTRY ; FISHING ; FORESTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HUNTING ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEST REPELLANTS OR ATTRACTANTS ; PLANT GROWTH REGULATORS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF ; TRAPPING</subject><creationdate>2012</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20121204&DB=EPODOC&CC=US&NR=8324221B2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20121204&DB=EPODOC&CC=US&NR=8324221B2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MITCHELL IAN S</creatorcontrib><creatorcontrib>HENTEMANN MARTIN F</creatorcontrib><creatorcontrib>SAMMOND DOUGLAS M</creatorcontrib><creatorcontrib>XU RUI</creatorcontrib><creatorcontrib>BENCSIK JOSEF R</creatorcontrib><creatorcontrib>WALLACE ELI M</creatorcontrib><creatorcontrib>FONG KIN CHIU</creatorcontrib><creatorcontrib>BANKA ANNA L</creatorcontrib><creatorcontrib>TANG TONY</creatorcontrib><creatorcontrib>BLAKE JAMES F</creatorcontrib><title>Pyrimidyl cyclopentanes as Akt protein kinase inhibitors</title><description>The present invention provides compounds of Formula (I) including tautomers, resolved enantiomers, resolved diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as Akt protein kinase inhibitors and for the treatment of Akt-mediated diseases, for example, hyperproliferative diseases such as cancer.</description><subject>AGRICULTURE</subject><subject>ANIMAL HUSBANDRY</subject><subject>BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES</subject><subject>CHEMISTRY</subject><subject>FISHING</subject><subject>FORESTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HUNTING</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEST REPELLANTS OR ATTRACTANTS</subject><subject>PLANT GROWTH REGULATORS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF</subject><subject>TRAPPING</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2012</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLAIqCzKzM1MqcxRSK5MzskvSM0rScxLLVZILFZwzC5RKCjKL0nNzFPIzsxLLE5VyMzLyEzKLMkvKuZhYE1LzClO5YXS3AwKbq4hzh66qQX58anFBYnJqXmpJfGhwRbGRiZGRoZORsZEKAEA7acugw</recordid><startdate>20121204</startdate><enddate>20121204</enddate><creator>MITCHELL IAN S</creator><creator>HENTEMANN MARTIN F</creator><creator>SAMMOND DOUGLAS M</creator><creator>XU RUI</creator><creator>BENCSIK JOSEF R</creator><creator>WALLACE ELI M</creator><creator>FONG KIN CHIU</creator><creator>BANKA ANNA L</creator><creator>TANG TONY</creator><creator>BLAKE JAMES F</creator><scope>EVB</scope></search><sort><creationdate>20121204</creationdate><title>Pyrimidyl cyclopentanes as Akt protein kinase inhibitors</title><author>MITCHELL IAN S ; HENTEMANN MARTIN F ; SAMMOND DOUGLAS M ; XU RUI ; BENCSIK JOSEF R ; WALLACE ELI M ; FONG KIN CHIU ; BANKA ANNA L ; TANG TONY ; BLAKE JAMES F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US8324221B23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2012</creationdate><topic>AGRICULTURE</topic><topic>ANIMAL HUSBANDRY</topic><topic>BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES</topic><topic>CHEMISTRY</topic><topic>FISHING</topic><topic>FORESTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HUNTING</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEST REPELLANTS OR ATTRACTANTS</topic><topic>PLANT GROWTH REGULATORS</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF</topic><topic>TRAPPING</topic><toplevel>online_resources</toplevel><creatorcontrib>MITCHELL IAN S</creatorcontrib><creatorcontrib>HENTEMANN MARTIN F</creatorcontrib><creatorcontrib>SAMMOND DOUGLAS M</creatorcontrib><creatorcontrib>XU RUI</creatorcontrib><creatorcontrib>BENCSIK JOSEF R</creatorcontrib><creatorcontrib>WALLACE ELI M</creatorcontrib><creatorcontrib>FONG KIN CHIU</creatorcontrib><creatorcontrib>BANKA ANNA L</creatorcontrib><creatorcontrib>TANG TONY</creatorcontrib><creatorcontrib>BLAKE JAMES F</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MITCHELL IAN S</au><au>HENTEMANN MARTIN F</au><au>SAMMOND DOUGLAS M</au><au>XU RUI</au><au>BENCSIK JOSEF R</au><au>WALLACE ELI M</au><au>FONG KIN CHIU</au><au>BANKA ANNA L</au><au>TANG TONY</au><au>BLAKE JAMES F</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Pyrimidyl cyclopentanes as Akt protein kinase inhibitors</title><date>2012-12-04</date><risdate>2012</risdate><abstract>The present invention provides compounds of Formula (I) including tautomers, resolved enantiomers, resolved diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as Akt protein kinase inhibitors and for the treatment of Akt-mediated diseases, for example, hyperproliferative diseases such as cancer.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | AGRICULTURE ANIMAL HUSBANDRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES CHEMISTRY FISHING FORESTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HUNTING HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEST REPELLANTS OR ATTRACTANTS PLANT GROWTH REGULATORS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF TRAPPING |
| title | Pyrimidyl cyclopentanes as Akt protein kinase inhibitors |
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