Phosphine transition metal complex, process for producing same, and anticancer agent

An anticancer agent having a novel chemical structure and high anticancer activity is provided. A phosphine transition metal complex of general formula (1) and an anticancer agent containing the complex are disclosed. R1 and R2, which may be the same or different, each represent a group having 1 to...

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Hauptverfasser: OOHARA NOBUHIKO, KANEDA YOSHIROU, OHTO KEISUKE, KODAMA HIROAKI, NAKATSUI KAZUHIRO
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creator OOHARA NOBUHIKO
KANEDA YOSHIROU
OHTO KEISUKE
KODAMA HIROAKI
NAKATSUI KAZUHIRO
description An anticancer agent having a novel chemical structure and high anticancer activity is provided. A phosphine transition metal complex of general formula (1) and an anticancer agent containing the complex are disclosed. R1 and R2, which may be the same or different, each represent a group having 1 to 10 carbon atoms selected from a straight-chain or branched alkyl group, a cycloalkyl group, a substituted cycloalkyl group, an adamantyl group, a phenyl group, and a substituted phenyl group; R3 and R4, which may be the same or different, each represent a hydrogen atom, a straight-chain alkyl group having 1 to 6 carbon atoms or branched alkyl group having 1 to 6 carbon atoms; or R3 and R4 are taken together to form a saturated or unsaturated ring which may have a substituted group; M represents a transition metal atom selected from the group consisting of gold, copper, and silver; and X− represents an anion.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title Phosphine transition metal complex, process for producing same, and anticancer agent
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