Osmotic device containing amantadine and an osmotic salt

Osmotic device containing amantadine and an osmotic salt

The osmotic devices of the present invention contain a unitary core comprising a salt of amantadine and an osmotic salt, wherein the two salts have an ion in common. The release rate of the amantadine is modified from a first order release profile to a zero order, pseudo-zero order or sigmoidal rele...

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Hauptverfasser: COPPARI MARCELO A, FELEDER ETHEL C, MEYER GLENN A, FAOUR JOAQUINA, BEFUMO MARCELO F, RICCI MARCELO A, VERGEZ JUAN A
Format: Patent
Sprache:eng
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator COPPARI MARCELO A
FELEDER ETHEL C
MEYER GLENN A
FAOUR JOAQUINA
BEFUMO MARCELO F
RICCI MARCELO A
VERGEZ JUAN A
description The osmotic devices of the present invention contain a unitary core comprising a salt of amantadine and an osmotic salt, wherein the two salts have an ion in common. The release rate of the amantadine is modified from a first order release profile to a zero order, pseudo-zero order or sigmoidal release profile by increasing the amount of the osmotic salt in the core of the device. The osmotic device includes a semipermeable membrane having a controlled porosity that can be adapted as needed to cooperate with the osmotic salt in providing a predetermined drug release profile. The osmotic salt need not be coated and it is in admixture with the amantadine salt.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title Osmotic device containing amantadine and an osmotic salt
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