Chimeric proteins that induce effects directed against viruses
The present invention is related to the obtaining of chimeric chains coding for proteins capable of inducing, in the recipient, a serotype-specific and protective humoral immune response against the infection by the Dengue virus, thus eliminating the effects of the serotype-nonespecific viral immuno...
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| creator | RODRIGUEZ RICARDO DE LA C. SILVA PEREZ RAUL RAFAEL ESPINOSA NIETO GERARDO ENRIQUE GUILLEN ABARRATEGUI CARLOS LOPEZ TIRADO MARIA GUADALUPE GUZMAN VAZQUEZ LAURA LAZO CRUZ LISSET HERMIDA DIAZ RAYNER RODRIGUEZ PRADO IRIS VALDES SANTIAGO GLAY CHINEA MORALES AIDA ZULUETA VAZQUEZ BEATRIZ DE LA CARIDAD SIERRA |
| description | The present invention is related to the obtaining of chimeric chains coding for proteins capable of inducing, in the recipient, a serotype-specific and protective humoral immune response against the infection by the Dengue virus, thus eliminating the effects of the serotype-nonespecific viral immunoenhancement that causes hemorrhagies and clinical complications described for this kind of pathology. These chimeric chains of nucleic acids are composed by the specific combination of fragments belonging to the gene of a mutated protein from Neisseria meningitidis with dehydrogenase activity and fragments that codify for a region of the envelope (E) protein from the Dengue virus which, when inserted to an expression vector, give rise to chimeric proteins with particular properties. The resultant chimeric molecules from this invention are applicable to the pharmaceutical industry for the obtaining of vaccine preparations and diagnostic means of high serotype-specificity to be used in humans. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_US8105606B2</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>US8105606B2</sourcerecordid><originalsourceid>FETCH-epo_espacenet_US8105606B23</originalsourceid><addsrcrecordid>eNrjZLBzzsjMTS3KTFYoKMovSc3MK1YoyUgsUcjMSylNTlVITUtLTS4pVkjJLALSqSkKiemJQDUlCmWZRaXFqcU8DKxpiTnFqbxQmptBwc01xNlDN7UgPz61uCAxOTUvtSQ-NNjC0MDUzMDMyciYCCUAIucwqA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Chimeric proteins that induce effects directed against viruses</title><source>esp@cenet</source><creator>RODRIGUEZ RICARDO DE LA C. SILVA ; PEREZ RAUL RAFAEL ESPINOSA ; NIETO GERARDO ENRIQUE GUILLEN ; ABARRATEGUI CARLOS LOPEZ ; TIRADO MARIA GUADALUPE GUZMAN ; VAZQUEZ LAURA LAZO ; CRUZ LISSET HERMIDA ; DIAZ RAYNER RODRIGUEZ ; PRADO IRIS VALDES ; SANTIAGO GLAY CHINEA ; MORALES AIDA ZULUETA ; VAZQUEZ BEATRIZ DE LA CARIDAD SIERRA</creator><creatorcontrib>RODRIGUEZ RICARDO DE LA C. SILVA ; PEREZ RAUL RAFAEL ESPINOSA ; NIETO GERARDO ENRIQUE GUILLEN ; ABARRATEGUI CARLOS LOPEZ ; TIRADO MARIA GUADALUPE GUZMAN ; VAZQUEZ LAURA LAZO ; CRUZ LISSET HERMIDA ; DIAZ RAYNER RODRIGUEZ ; PRADO IRIS VALDES ; SANTIAGO GLAY CHINEA ; MORALES AIDA ZULUETA ; VAZQUEZ BEATRIZ DE LA CARIDAD SIERRA</creatorcontrib><description>The present invention is related to the obtaining of chimeric chains coding for proteins capable of inducing, in the recipient, a serotype-specific and protective humoral immune response against the infection by the Dengue virus, thus eliminating the effects of the serotype-nonespecific viral immunoenhancement that causes hemorrhagies and clinical complications described for this kind of pathology. These chimeric chains of nucleic acids are composed by the specific combination of fragments belonging to the gene of a mutated protein from Neisseria meningitidis with dehydrogenase activity and fragments that codify for a region of the envelope (E) protein from the Dengue virus which, when inserted to an expression vector, give rise to chimeric proteins with particular properties. The resultant chimeric molecules from this invention are applicable to the pharmaceutical industry for the obtaining of vaccine preparations and diagnostic means of high serotype-specificity to be used in humans.</description><language>eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; COMPOSITIONS THEREOF ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2012</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120131&DB=EPODOC&CC=US&NR=8105606B2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120131&DB=EPODOC&CC=US&NR=8105606B2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>RODRIGUEZ RICARDO DE LA C. SILVA</creatorcontrib><creatorcontrib>PEREZ RAUL RAFAEL ESPINOSA</creatorcontrib><creatorcontrib>NIETO GERARDO ENRIQUE GUILLEN</creatorcontrib><creatorcontrib>ABARRATEGUI CARLOS LOPEZ</creatorcontrib><creatorcontrib>TIRADO MARIA GUADALUPE GUZMAN</creatorcontrib><creatorcontrib>VAZQUEZ LAURA LAZO</creatorcontrib><creatorcontrib>CRUZ LISSET HERMIDA</creatorcontrib><creatorcontrib>DIAZ RAYNER RODRIGUEZ</creatorcontrib><creatorcontrib>PRADO IRIS VALDES</creatorcontrib><creatorcontrib>SANTIAGO GLAY CHINEA</creatorcontrib><creatorcontrib>MORALES AIDA ZULUETA</creatorcontrib><creatorcontrib>VAZQUEZ BEATRIZ DE LA CARIDAD SIERRA</creatorcontrib><title>Chimeric proteins that induce effects directed against viruses</title><description>The present invention is related to the obtaining of chimeric chains coding for proteins capable of inducing, in the recipient, a serotype-specific and protective humoral immune response against the infection by the Dengue virus, thus eliminating the effects of the serotype-nonespecific viral immunoenhancement that causes hemorrhagies and clinical complications described for this kind of pathology. These chimeric chains of nucleic acids are composed by the specific combination of fragments belonging to the gene of a mutated protein from Neisseria meningitidis with dehydrogenase activity and fragments that codify for a region of the envelope (E) protein from the Dengue virus which, when inserted to an expression vector, give rise to chimeric proteins with particular properties. The resultant chimeric molecules from this invention are applicable to the pharmaceutical industry for the obtaining of vaccine preparations and diagnostic means of high serotype-specificity to be used in humans.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>COMPOSITIONS THEREOF</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2012</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLBzzsjMTS3KTFYoKMovSc3MK1YoyUgsUcjMSylNTlVITUtLTS4pVkjJLALSqSkKiemJQDUlCmWZRaXFqcU8DKxpiTnFqbxQmptBwc01xNlDN7UgPz61uCAxOTUvtSQ-NNjC0MDUzMDMyciYCCUAIucwqA</recordid><startdate>20120131</startdate><enddate>20120131</enddate><creator>RODRIGUEZ RICARDO DE LA C. 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SILVA ; PEREZ RAUL RAFAEL ESPINOSA ; NIETO GERARDO ENRIQUE GUILLEN ; ABARRATEGUI CARLOS LOPEZ ; TIRADO MARIA GUADALUPE GUZMAN ; VAZQUEZ LAURA LAZO ; CRUZ LISSET HERMIDA ; DIAZ RAYNER RODRIGUEZ ; PRADO IRIS VALDES ; SANTIAGO GLAY CHINEA ; MORALES AIDA ZULUETA ; VAZQUEZ BEATRIZ DE LA CARIDAD SIERRA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US8105606B23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2012</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>COMPOSITIONS THEREOF</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>RODRIGUEZ RICARDO DE LA C. SILVA</creatorcontrib><creatorcontrib>PEREZ RAUL RAFAEL ESPINOSA</creatorcontrib><creatorcontrib>NIETO GERARDO ENRIQUE GUILLEN</creatorcontrib><creatorcontrib>ABARRATEGUI CARLOS LOPEZ</creatorcontrib><creatorcontrib>TIRADO MARIA GUADALUPE GUZMAN</creatorcontrib><creatorcontrib>VAZQUEZ LAURA LAZO</creatorcontrib><creatorcontrib>CRUZ LISSET HERMIDA</creatorcontrib><creatorcontrib>DIAZ RAYNER RODRIGUEZ</creatorcontrib><creatorcontrib>PRADO IRIS VALDES</creatorcontrib><creatorcontrib>SANTIAGO GLAY CHINEA</creatorcontrib><creatorcontrib>MORALES AIDA ZULUETA</creatorcontrib><creatorcontrib>VAZQUEZ BEATRIZ DE LA CARIDAD SIERRA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>RODRIGUEZ RICARDO DE LA C. SILVA</au><au>PEREZ RAUL RAFAEL ESPINOSA</au><au>NIETO GERARDO ENRIQUE GUILLEN</au><au>ABARRATEGUI CARLOS LOPEZ</au><au>TIRADO MARIA GUADALUPE GUZMAN</au><au>VAZQUEZ LAURA LAZO</au><au>CRUZ LISSET HERMIDA</au><au>DIAZ RAYNER RODRIGUEZ</au><au>PRADO IRIS VALDES</au><au>SANTIAGO GLAY CHINEA</au><au>MORALES AIDA ZULUETA</au><au>VAZQUEZ BEATRIZ DE LA CARIDAD SIERRA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Chimeric proteins that induce effects directed against viruses</title><date>2012-01-31</date><risdate>2012</risdate><abstract>The present invention is related to the obtaining of chimeric chains coding for proteins capable of inducing, in the recipient, a serotype-specific and protective humoral immune response against the infection by the Dengue virus, thus eliminating the effects of the serotype-nonespecific viral immunoenhancement that causes hemorrhagies and clinical complications described for this kind of pathology. These chimeric chains of nucleic acids are composed by the specific combination of fragments belonging to the gene of a mutated protein from Neisseria meningitidis with dehydrogenase activity and fragments that codify for a region of the envelope (E) protein from the Dengue virus which, when inserted to an expression vector, give rise to chimeric proteins with particular properties. The resultant chimeric molecules from this invention are applicable to the pharmaceutical industry for the obtaining of vaccine preparations and diagnostic means of high serotype-specificity to be used in humans.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | Chimeric proteins that induce effects directed against viruses |
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