Method of assessing the proliferation or differentiation behaviour of a population of target cells in a biological system

The invention relates to a method of assessing the proliferation or differentiation behavior of a population of target cells in a biological system, said method comprising the steps of; [a] measuring the value of at least one proliferation characteristic of said cells at least one time point t, wher...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	JONES PHILIP HOWLETT, SIMONS BENJAMIN DAVID
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES TESTING
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

container_end_page
container_issue
container_start_page
container_title
container_volume
creator	JONES PHILIP HOWLETT SIMONS BENJAMIN DAVID
description	The invention relates to a method of assessing the proliferation or differentiation behavior of a population of target cells in a biological system, said method comprising the steps of; [a] measuring the value of at least one proliferation characteristic of said cells at least one time point t, wherein said proliferation characteristic is the clone size distribution; [b] comparing the clone size distribution measured in [a] to a reference clone size distribution at a corresponding time point t predicted or described by the equation; wherein a difference between the measured clone size distribution of [a] and the predicted or described clone size distribution of [b] indicates an altered proliferation or differentiation behavior of said cells. The invention further relates to methods involving assessing the scaling form of the above behaviors, values of the parameters, and inferring effects on cell proliferation and/or differentiation therefrom.
format	Patent
fullrecord	<record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_US8103455B2</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>US8103455B2</sourcerecordid><originalsourceid>FETCH-epo_espacenet_US8103455B23</originalsourceid><addsrcrecordid>eNqNi0EKwkAMRbtxIeodcgFBrQXXiuLGlbou0zbTBuJkmKRCb2_RHsDV5__3_jwbbmidNCAenCqqUmjBOoSYhMljckYSQBI05MeKweg3Vdi5N0mfvl-IEnueZA_mUosGNTIrUBh5RcLSUu0YdFDD1zKbeceKqykXGVzOj9N1jVFK1OhqDGjl837YbvJ9URx3-R_KB8VRRs4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Method of assessing the proliferation or differentiation behaviour of a population of target cells in a biological system</title><source>esp@cenet</source><creator>JONES PHILIP HOWLETT ; SIMONS BENJAMIN DAVID</creator><creatorcontrib>JONES PHILIP HOWLETT ; SIMONS BENJAMIN DAVID</creatorcontrib><description>The invention relates to a method of assessing the proliferation or differentiation behavior of a population of target cells in a biological system, said method comprising the steps of; [a] measuring the value of at least one proliferation characteristic of said cells at least one time point t, wherein said proliferation characteristic is the clone size distribution; [b] comparing the clone size distribution measured in [a] to a reference clone size distribution at a corresponding time point t predicted or described by the equation; wherein a difference between the measured clone size distribution of [a] and the predicted or described clone size distribution of [b] indicates an altered proliferation or differentiation behavior of said cells. The invention further relates to methods involving assessing the scaling form of the above behaviors, values of the parameters, and inferring effects on cell proliferation and/or differentiation therefrom.</description><language>eng</language><subject>HUMAN NECESSITIES ; HYGIENE ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEDICAL OR VETERINARY SCIENCE ; PHYSICS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; TESTING</subject><creationdate>2012</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120124&DB=EPODOC&CC=US&NR=8103455B2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76418</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120124&DB=EPODOC&CC=US&NR=8103455B2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>JONES PHILIP HOWLETT</creatorcontrib><creatorcontrib>SIMONS BENJAMIN DAVID</creatorcontrib><title>Method of assessing the proliferation or differentiation behaviour of a population of target cells in a biological system</title><description>The invention relates to a method of assessing the proliferation or differentiation behavior of a population of target cells in a biological system, said method comprising the steps of; [a] measuring the value of at least one proliferation characteristic of said cells at least one time point t, wherein said proliferation characteristic is the clone size distribution; [b] comparing the clone size distribution measured in [a] to a reference clone size distribution at a corresponding time point t predicted or described by the equation; wherein a difference between the measured clone size distribution of [a] and the predicted or described clone size distribution of [b] indicates an altered proliferation or differentiation behavior of said cells. The invention further relates to methods involving assessing the scaling form of the above behaviors, values of the parameters, and inferring effects on cell proliferation and/or differentiation therefrom.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PHYSICS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>TESTING</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2012</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNi0EKwkAMRbtxIeodcgFBrQXXiuLGlbou0zbTBuJkmKRCb2_RHsDV5__3_jwbbmidNCAenCqqUmjBOoSYhMljckYSQBI05MeKweg3Vdi5N0mfvl-IEnueZA_mUosGNTIrUBh5RcLSUu0YdFDD1zKbeceKqykXGVzOj9N1jVFK1OhqDGjl837YbvJ9URx3-R_KB8VRRs4</recordid><startdate>20120124</startdate><enddate>20120124</enddate><creator>JONES PHILIP HOWLETT</creator><creator>SIMONS BENJAMIN DAVID</creator><scope>EVB</scope></search><sort><creationdate>20120124</creationdate><title>Method of assessing the proliferation or differentiation behaviour of a population of target cells in a biological system</title><author>JONES PHILIP HOWLETT ; SIMONS BENJAMIN DAVID</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US8103455B23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2012</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PHYSICS</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>TESTING</topic><toplevel>online_resources</toplevel><creatorcontrib>JONES PHILIP HOWLETT</creatorcontrib><creatorcontrib>SIMONS BENJAMIN DAVID</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>JONES PHILIP HOWLETT</au><au>SIMONS BENJAMIN DAVID</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Method of assessing the proliferation or differentiation behaviour of a population of target cells in a biological system</title><date>2012-01-24</date><risdate>2012</risdate><abstract>The invention relates to a method of assessing the proliferation or differentiation behavior of a population of target cells in a biological system, said method comprising the steps of; [a] measuring the value of at least one proliferation characteristic of said cells at least one time point t, wherein said proliferation characteristic is the clone size distribution; [b] comparing the clone size distribution measured in [a] to a reference clone size distribution at a corresponding time point t predicted or described by the equation; wherein a difference between the measured clone size distribution of [a] and the predicted or described clone size distribution of [b] indicates an altered proliferation or differentiation behavior of said cells. The invention further relates to methods involving assessing the scaling form of the above behaviors, values of the parameters, and inferring effects on cell proliferation and/or differentiation therefrom.</abstract><oa>free_for_read</oa></addata></record>
fulltext	fulltext_linktorsrc
identifier
ispartof
issn
language	eng
recordid	cdi_epo_espacenet_US8103455B2
source	esp@cenet
subjects	HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES TESTING
title	Method of assessing the proliferation or differentiation behaviour of a population of target cells in a biological system
url	https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T13%3A54%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=JONES%20PHILIP%20HOWLETT&rft.date=2012-01-24&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EUS8103455B2%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true