Pharmaceutical composition containing polypeptide fragments of serralysins

The present invention is related to a composition capable of inhibiting the growth of tumoral cells of different histological origins and of activated endothelial cells. The components of said compositions are polypeptide fragments of the serralisins, corresponding to the C-terminal fragment, from t...

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Hauptverfasser:	PEREZ MARIA DEL CARMEN ABRAHANTES, GONZALEZ JESUS REYES, RIOS GLORIA VELIZ, GONZALEZ CARIDAD ANAIS GASMURI, ROMERO MONICA BEQUET, COWLEY JORGE VICTOR GAVILONDO, SUAREZ JOSE GARCIA, DIAZ EDUARDO MARTINEZ, SERRA LILA ROSA CASTELLANOS, LOPEZ LUIS JAVIER GONZALEZ, SOSA MANUEL SELMAN-HOUSEIN, RIERA RAUL GOMEZ
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention is related to a composition capable of inhibiting the growth of tumoral cells of different histological origins and of activated endothelial cells. The components of said compositions are polypeptide fragments of the serralisins, corresponding to the C-terminal fragment, from the internal metionine trough the end of the molecule, which could be combined among them and optionally with the prodigiosins that potentiate the antitumoral effect of the composition. The prodigiosins in the composition could be at a concentration of 0.1-100 nM. The anti-proliferative action of this composition is mediated by apoptotic mechanism. It's "in vivo" administration has antitumoral, antiangiogenic and protective effect against malignant tumors.