Methods for inhibiting the activity of the P40 subunit of human IL-12

Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12 ) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an...

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Hauptverfasser:	VENTURINI AMY, KAYMAKCALAN ZEHRA, VELDMAN GEERTRUIDA M, WIDOM ANGELA, WHITE MICHAEL, SMITH STEPHEN, SAKORAFAS PAUL, SALFELD JOCHEN G, DUNCAN ALEXANDER ROBERT, FRIEDRICH STUART, ROGUSKA MICHAEL, PASKIND MICHAEL, LABKOVSKY BORIS, ELVIN JOHN GAWAIN, BANERJEE SUBHASHIS, KANTOR ANGELA, TRACEY DANIEL EDWARD, WARNE NICHOLAS W, DERBYSHIRE ELAINE JOY, CARMEN SARA, HOLTET THOR LAS, DU FOU SARAH LEILA
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPIRITS VINEGAR WINE
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