Artificial corneal implant

A material that can be applied as implants designed to artificially replace or augment the cornea, such as an artificial cornea, corneal onlay, or corneal inlay (intrastromal lens) is provided. The artificial corneal implant has a double network hydrogel with a first network interpenetrated with a s...

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Hauptverfasser: CARRASCO MICHAEL R, FRANK CURTIS W, KOH WON-GUN, MYUNG DAVID, NOOLANDI JAAN, HU YIN, SMITH ALAN J, TA CHRISTOPHER
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creator CARRASCO MICHAEL R
FRANK CURTIS W
KOH WON-GUN
MYUNG DAVID
NOOLANDI JAAN
HU YIN
SMITH ALAN J
TA CHRISTOPHER
description A material that can be applied as implants designed to artificially replace or augment the cornea, such as an artificial cornea, corneal onlay, or corneal inlay (intrastromal lens) is provided. The artificial corneal implant has a double network hydrogel with a first network interpenetrated with a second network. The first network and the second network are based on biocompatible polymers. At least one of the network polymers is based on a hydrophilic polymer. The artificial cornea or implant has epithelialization promoting biomolecules that are covalently linked to the surface of the double network hydrogel using an azide-active-ester chemical linker. Corneal epithelial cells or cornea-derived cells are adhered to the biomolecules. The double network has a physiologic diffusion coefficient to allow passage of nutrients to the adhered cells.
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subjects BANDAGES, DRESSINGS OR ABSORBENT PADS
DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS
FILTERS IMPLANTABLE INTO BLOOD VESSELS
FIRST-AID KITS
FOMENTATION
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROSTHESES
TREATMENT OR PROTECTION OF EYES OR EARS
title Artificial corneal implant
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