Process for the preparation of concentrated, sterile injectable solutions containing docetaxel
This invention describes a process for the production of ANHYDROUS active pharmaceutical ingredients (APIs); a process for the preparation of HYDRATED active pharmaceutical ingredients, a process for the preparation of sterile and stable injectable solutions, and their use, more specifically, APIs w...
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| creator | GUIMARAES ENEIDA MACHADO ANTONIO SANTINI MARCO ANTONIO SANTIAGO JUNIOR MARCIO SILVA MARIA MARANDUBA AURELIO |
| description | This invention describes a process for the production of ANHYDROUS active pharmaceutical ingredients (APIs); a process for the preparation of HYDRATED active pharmaceutical ingredients, a process for the preparation of sterile and stable injectable solutions, and their use, more specifically, APIs which are taxane derivatives, especially (2R,3S) 4-acetoxy-2-α-benzoyloxy-5 -20-epoxy-1,7- -10- -tri-hydroxy-9-oxo-tax-11-en-13α-il 3-tert-butoxy carbonylamino-2-hydroxy-3-phenylpropionate (I); 4-acetoxy-2-α-benzoyloxy-5- -20-epoxy-1,7 -10- -tri-hidroxy-9-oxo-tax-11-en-13α-il (2R,3S) 3-benzoylamino-2-hydroxy-3-phenylpropionate (II), and particularly 4-acetoxy-2-α-benzoyloxy-5 -20-epoxy-1, 7- -10- -tri-hidroxy-9-oxo-tax-11-en-13α-il (2R,3S) 3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate tri-hydrate (III). |
| format | Patent |
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a process for the preparation of HYDRATED active pharmaceutical ingredients, a process for the preparation of sterile and stable injectable solutions, and their use, more specifically, APIs which are taxane derivatives, especially (2R,3S) 4-acetoxy-2-α-benzoyloxy-5 -20-epoxy-1,7- -10- -tri-hydroxy-9-oxo-tax-11-en-13α-il 3-tert-butoxy carbonylamino-2-hydroxy-3-phenylpropionate (I); 4-acetoxy-2-α-benzoyloxy-5- -20-epoxy-1,7 -10- -tri-hidroxy-9-oxo-tax-11-en-13α-il (2R,3S) 3-benzoylamino-2-hydroxy-3-phenylpropionate (II), and particularly 4-acetoxy-2-α-benzoyloxy-5 -20-epoxy-1, 7- -10- -tri-hidroxy-9-oxo-tax-11-en-13α-il (2R,3S) 3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate tri-hydrate (III).</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2010</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjDEKAjEQRbexEPUOcwAtVBa3VhRLQW1dxuxfjYRMyIzg8c2CB7D6j8_jjavbKYuDKvWSyZ6glJE4s3mJJD05iQ7RyoFuTmrIPoB8fMEZ3wuqhPcg66Aa--jjg7rSNP4gTKtRz0Ex--2kosP-sjsukKSFJi5xWHs9b5p1U9fL7Wr9h_IFK8g9RA</recordid><startdate>20101123</startdate><enddate>20101123</enddate><creator>GUIMARAES ENEIDA</creator><creator>MACHADO ANTONIO</creator><creator>SANTINI MARCO ANTONIO</creator><creator>SANTIAGO JUNIOR MARCIO</creator><creator>SILVA MARIA</creator><creator>MARANDUBA AURELIO</creator><scope>EVB</scope></search><sort><creationdate>20101123</creationdate><title>Process for the preparation of concentrated, sterile injectable solutions containing docetaxel</title><author>GUIMARAES ENEIDA ; 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a process for the preparation of HYDRATED active pharmaceutical ingredients, a process for the preparation of sterile and stable injectable solutions, and their use, more specifically, APIs which are taxane derivatives, especially (2R,3S) 4-acetoxy-2-α-benzoyloxy-5 -20-epoxy-1,7- -10- -tri-hydroxy-9-oxo-tax-11-en-13α-il 3-tert-butoxy carbonylamino-2-hydroxy-3-phenylpropionate (I); 4-acetoxy-2-α-benzoyloxy-5- -20-epoxy-1,7 -10- -tri-hidroxy-9-oxo-tax-11-en-13α-il (2R,3S) 3-benzoylamino-2-hydroxy-3-phenylpropionate (II), and particularly 4-acetoxy-2-α-benzoyloxy-5 -20-epoxy-1, 7- -10- -tri-hidroxy-9-oxo-tax-11-en-13α-il (2R,3S) 3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate tri-hydrate (III).</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | Process for the preparation of concentrated, sterile injectable solutions containing docetaxel |
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