Process for the resolution of racemic verapamil

Process for the resolution of racemic verapamil

A new process is described for the resolution of racemic verapamil, which allows the desired enantiomer to be obtained in high yields and with high enantiomeric purity. The process uses optically active 2,3-bis[(2-fluorobenzoyl)oxy]butanedioic acid as the resolving agent, and a water/dimethylformami...

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Hauptverfasser: LUSSANA MASSIMILIANO, PIZZATTI ENRICA, LANDONIO ERNESTO, VIGANO' ENRICO, BERTOLOTTI CHIARA
Format: Patent
Sprache:eng
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ACYCLIC OR CARBOCYCLIC COMPOUNDS
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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creator LUSSANA MASSIMILIANO
PIZZATTI ENRICA
LANDONIO ERNESTO
VIGANO' ENRICO
BERTOLOTTI CHIARA
description A new process is described for the resolution of racemic verapamil, which allows the desired enantiomer to be obtained in high yields and with high enantiomeric purity. The process uses optically active 2,3-bis[(2-fluorobenzoyl)oxy]butanedioic acid as the resolving agent, and a water/dimethylformamide or water/acetonitrile or water/methanol mixture, as the reaction solvent.
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subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
title Process for the resolution of racemic verapamil
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