Process for the purification of perindopril

Process for the purification of perindopril

A dicyclohexyamine salt of compound of formula I, namely perindopril, having an X-ray powder diffraction pattern with characteristic peaks (2 ): 8.462, 10.624, 18.693, 9.424, 17.272, 14.177, 19.499, 20.765, 21.409, and 14.540. A process for preparation of the said salt of perindopril and its use in...

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Hauptverfasser: DHAKE VILAS NATHU, GODBOLE HIMANSHU MADHAV, TAMBE SUHAS GANPAT, NEHATE SAGAR PURUSHOTTAM, RANANAWARE UMESH BABANRAO, SINGH GIRIJ PAL
Format: Patent
Sprache:eng
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator DHAKE VILAS NATHU
GODBOLE HIMANSHU MADHAV
TAMBE SUHAS GANPAT
NEHATE SAGAR PURUSHOTTAM
RANANAWARE UMESH BABANRAO
SINGH GIRIJ PAL
description A dicyclohexyamine salt of compound of formula I, namely perindopril, having an X-ray powder diffraction pattern with characteristic peaks (2 ): 8.462, 10.624, 18.693, 9.424, 17.272, 14.177, 19.499, 20.765, 21.409, and 14.540. A process for preparation of the said salt of perindopril and its use in the purification of an impure perindopril and a process for purification of perindropril comprising formation of its salt with dicyclohexylamine. The present invention also relates to preparation of Perindopril tert-butyl amine salt directly from Perindopril dicyclohexylamine salt without isolating the free base.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title Process for the purification of perindopril
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