High purity butoconazole nitrate with specified particle size and a process for the preparation thereof

High purity butoconazole nitrate with specified particle size and a process for the preparation thereof

One object of the invention is high purity butoconazole nitrate of the formula (I) (I) containing maximum 0.1 wt % of chemical impurities, wherein at least 95% of the particles of the substance are below 75 mum by diameter, whereas at least 99% of the particles are below 250 mum by diameter, and pro...

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Hauptverfasser: DOBAY LASZLO, WERKNE PAPP EVA, SEBOK FERENC, CZIBULA LASZLO, NAGYNE BAGDY JUDIT
Format: Patent
Sprache:eng
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator DOBAY LASZLO
WERKNE PAPP EVA
SEBOK FERENC
CZIBULA LASZLO
NAGYNE BAGDY JUDIT
description One object of the invention is high purity butoconazole nitrate of the formula (I) (I) containing maximum 0.1 wt % of chemical impurities, wherein at least 95% of the particles of the substance are below 75 mum by diameter, whereas at least 99% of the particles are below 250 mum by diameter, and process for its preparation. A pharmaceutical composition comprising as active ingredient, high purity butoconazole nitrate of specified particle size in admixture with known auxiliaries is also within the scope of the invention.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title High purity butoconazole nitrate with specified particle size and a process for the preparation thereof
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