Dihydrospiro[dibenzo[a,d][7]annulene-5,4'-imidazol] compounds for the inhibition of beta-secretase

Dihydrospiro[dibenzo[a,d][7]annulene-5,4'-imidazol] compounds for the inhibition of beta-secretase

The present invention provides a 10,11-dihydrospiro[dibenzo[a,d][7]annulene -5,4'-imidazol]-5'(1'H)-one compound of formula I Also provided are methods and compositions for the inhibition of beta-secretase (BACE) and the treatment of beta-amyloid deposits and neurofibrillary tangles.

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Bibliographische Detailangaben
Hauptverfasser: ANDRAE PATRICK MICHAEL, QUAGLIATO DOMINICK ANTHONY, FAN YI
Format: Patent
Sprache:eng
Schlagworte:
AGRICULTURE
ANIMAL HUSBANDRY
BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
CHEMISTRY
FISHING
FORESTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HUNTING
METALLURGY
ORGANIC CHEMISTRY
PEST REPELLANTS OR ATTRACTANTS
PLANT GROWTH REGULATORS
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF
TRAPPING
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Beschreibung
Zusammenfassung:The present invention provides a 10,11-dihydrospiro[dibenzo[a,d][7]annulene -5,4'-imidazol]-5'(1'H)-one compound of formula I Also provided are methods and compositions for the inhibition of beta-secretase (BACE) and the treatment of beta-amyloid deposits and neurofibrillary tangles.