Process suitable for industrial scale production of gabapentin

Process suitable for industrial scale production of gabapentin

This invention relates to an improved process for the preparation of substantially pure, stable anhydrous gabapentin. Thus, cyclohexane 1,1-diacetic acid monoamide is first treated with NaOH/NaClO to form 3,3-pentamethylenebutyrolactam, which is treated with aqueous HCl solution under reflux to prov...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: LIU TIANCHUN, HUANG YOUMING, FAN WEIRONG
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title
container_volume
creator LIU TIANCHUN
HUANG YOUMING
FAN WEIRONG
description This invention relates to an improved process for the preparation of substantially pure, stable anhydrous gabapentin. Thus, cyclohexane 1,1-diacetic acid monoamide is first treated with NaOH/NaClO to form 3,3-pentamethylenebutyrolactam, which is treated with aqueous HCl solution under reflux to provide gabapentin HCl salt, which is then neutralized with NaOH followed by a dehydration step to provide substantially pure, storage-stable, pharmaceutical grade gabapentin.
format Patent
fullrecord <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_US7442834B2</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>US7442834B2</sourcerecordid><originalsourceid>FETCH-epo_espacenet_US7442834B23</originalsourceid><addsrcrecordid>eNrjZLALKMpPTi0uViguzSxJTMpJVUjLL1LIzEspLS4pykzMUShOTgQKFhTlp5Qml2Tm5ynkpymkJyYlFqTmlWTm8TCwpiXmFKfyQmluBgU31xBnD93Ugvz41OKCxOTUvNSS-NBgcxMTIwtjEycjYyKUAAA38DDS</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Process suitable for industrial scale production of gabapentin</title><source>esp@cenet</source><creator>LIU TIANCHUN ; HUANG YOUMING ; FAN WEIRONG</creator><creatorcontrib>LIU TIANCHUN ; HUANG YOUMING ; FAN WEIRONG</creatorcontrib><description>This invention relates to an improved process for the preparation of substantially pure, stable anhydrous gabapentin. Thus, cyclohexane 1,1-diacetic acid monoamide is first treated with NaOH/NaClO to form 3,3-pentamethylenebutyrolactam, which is treated with aqueous HCl solution under reflux to provide gabapentin HCl salt, which is then neutralized with NaOH followed by a dehydration step to provide substantially pure, storage-stable, pharmaceutical grade gabapentin.</description><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2008</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20081028&amp;DB=EPODOC&amp;CC=US&amp;NR=7442834B2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20081028&amp;DB=EPODOC&amp;CC=US&amp;NR=7442834B2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LIU TIANCHUN</creatorcontrib><creatorcontrib>HUANG YOUMING</creatorcontrib><creatorcontrib>FAN WEIRONG</creatorcontrib><title>Process suitable for industrial scale production of gabapentin</title><description>This invention relates to an improved process for the preparation of substantially pure, stable anhydrous gabapentin. Thus, cyclohexane 1,1-diacetic acid monoamide is first treated with NaOH/NaClO to form 3,3-pentamethylenebutyrolactam, which is treated with aqueous HCl solution under reflux to provide gabapentin HCl salt, which is then neutralized with NaOH followed by a dehydration step to provide substantially pure, storage-stable, pharmaceutical grade gabapentin.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2008</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLALKMpPTi0uViguzSxJTMpJVUjLL1LIzEspLS4pykzMUShOTgQKFhTlp5Qml2Tm5ynkpymkJyYlFqTmlWTm8TCwpiXmFKfyQmluBgU31xBnD93Ugvz41OKCxOTUvNSS-NBgcxMTIwtjEycjYyKUAAA38DDS</recordid><startdate>20081028</startdate><enddate>20081028</enddate><creator>LIU TIANCHUN</creator><creator>HUANG YOUMING</creator><creator>FAN WEIRONG</creator><scope>EVB</scope></search><sort><creationdate>20081028</creationdate><title>Process suitable for industrial scale production of gabapentin</title><author>LIU TIANCHUN ; HUANG YOUMING ; FAN WEIRONG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US7442834B23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2008</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>LIU TIANCHUN</creatorcontrib><creatorcontrib>HUANG YOUMING</creatorcontrib><creatorcontrib>FAN WEIRONG</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LIU TIANCHUN</au><au>HUANG YOUMING</au><au>FAN WEIRONG</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Process suitable for industrial scale production of gabapentin</title><date>2008-10-28</date><risdate>2008</risdate><abstract>This invention relates to an improved process for the preparation of substantially pure, stable anhydrous gabapentin. Thus, cyclohexane 1,1-diacetic acid monoamide is first treated with NaOH/NaClO to form 3,3-pentamethylenebutyrolactam, which is treated with aqueous HCl solution under reflux to provide gabapentin HCl salt, which is then neutralized with NaOH followed by a dehydration step to provide substantially pure, storage-stable, pharmaceutical grade gabapentin.</abstract><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier
ispartof
issn
language eng
recordid cdi_epo_espacenet_US7442834B2
source esp@cenet
subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
title Process suitable for industrial scale production of gabapentin
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T18%3A04%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=LIU%20TIANCHUN&rft.date=2008-10-28&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EUS7442834B2%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true