3-arylquinazoline derivatives as selective estrogen receptor beta modulators
Novel quinazoline derivatives possessing activity as estrogen receptor beta (ERbeta) modulators are provided which have the general formula I wherein X is O or S; A and B are each independently CR''' or N; R, R' and R'' are each independently hydrogen, alkyl, benzyl, p-...
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| creator | GUNGOR TIMUR CORTE JAMES R |
| description | Novel quinazoline derivatives possessing activity as estrogen receptor beta (ERbeta) modulators are provided which have the general formula I wherein X is O or S; A and B are each independently CR''' or N; R, R' and R'' are each independently hydrogen, alkyl, benzyl, p-methoxybenzyl, allyl, or Si(R4)3, wherein at least one of R, R' and R'' is hydrogen; R''' is hydrogen, halogen, CF3, OR5, S(O)nR6, NR7R8, cycloalkyl or alkyl; R1, R2 and R3 are each independently hydrogen, halogen, CF3, OR5, S(O)nR6, NR7R8, cycloalkyl or alkyl; R4 is a alkyl; R5, R6, R7 and R8 in each functional group are each independently hydrogen, cycloalkyl or alkyl; and n is an integer from 0 to 2. In addition, a method is provided for preventing, inhibiting or treating the progression or onset of pathological conditions associated with the estrogen receptor and to pharmaceutical compositions containing such compounds. |
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In addition, a method is provided for preventing, inhibiting or treating the progression or onset of pathological conditions associated with the estrogen receptor and to pharmaceutical compositions containing such compounds.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2008</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20080603&DB=EPODOC&CC=US&NR=7381730B2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20080603&DB=EPODOC&CC=US&NR=7381730B2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GUNGOR TIMUR</creatorcontrib><creatorcontrib>CORTE JAMES R</creatorcontrib><title>3-arylquinazoline derivatives as selective estrogen receptor beta modulators</title><description>Novel quinazoline derivatives possessing activity as estrogen receptor beta (ERbeta) modulators are provided which have the general formula I wherein X is O or S; A and B are each independently CR''' or N; R, R' and R'' are each independently hydrogen, alkyl, benzyl, p-methoxybenzyl, allyl, or Si(R4)3, wherein at least one of R, R' and R'' is hydrogen; R''' is hydrogen, halogen, CF3, OR5, S(O)nR6, NR7R8, cycloalkyl or alkyl; R1, R2 and R3 are each independently hydrogen, halogen, CF3, OR5, S(O)nR6, NR7R8, cycloalkyl or alkyl; R4 is a alkyl; R5, R6, R7 and R8 in each functional group are each independently hydrogen, cycloalkyl or alkyl; and n is an integer from 0 to 2. In addition, a method is provided for preventing, inhibiting or treating the progression or onset of pathological conditions associated with the estrogen receptor and to pharmaceutical compositions containing such compounds.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2008</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyjEKAjEQRuE0FqLeYS6woKZYa0XZwk6tlzH7K4GYZGeyC3p6FTyA1eODNzVHW7E8Qz_4yK8UfAR1ED9y8SOUWEkR4L4iaJF0RySBQy5J6IrC9EjdEPhDnZvJjYNi8evM0GF_3jUVcmqhmR0iSns51Xazqu1yu7Z_LG-vLjaV</recordid><startdate>20080603</startdate><enddate>20080603</enddate><creator>GUNGOR TIMUR</creator><creator>CORTE JAMES R</creator><scope>EVB</scope></search><sort><creationdate>20080603</creationdate><title>3-arylquinazoline derivatives as selective estrogen receptor beta modulators</title><author>GUNGOR TIMUR ; CORTE JAMES R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US7381730B23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2008</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>GUNGOR TIMUR</creatorcontrib><creatorcontrib>CORTE JAMES R</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>GUNGOR TIMUR</au><au>CORTE JAMES R</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>3-arylquinazoline derivatives as selective estrogen receptor beta modulators</title><date>2008-06-03</date><risdate>2008</risdate><abstract>Novel quinazoline derivatives possessing activity as estrogen receptor beta (ERbeta) modulators are provided which have the general formula I wherein X is O or S; A and B are each independently CR''' or N; R, R' and R'' are each independently hydrogen, alkyl, benzyl, p-methoxybenzyl, allyl, or Si(R4)3, wherein at least one of R, R' and R'' is hydrogen; R''' is hydrogen, halogen, CF3, OR5, S(O)nR6, NR7R8, cycloalkyl or alkyl; R1, R2 and R3 are each independently hydrogen, halogen, CF3, OR5, S(O)nR6, NR7R8, cycloalkyl or alkyl; R4 is a alkyl; R5, R6, R7 and R8 in each functional group are each independently hydrogen, cycloalkyl or alkyl; and n is an integer from 0 to 2. In addition, a method is provided for preventing, inhibiting or treating the progression or onset of pathological conditions associated with the estrogen receptor and to pharmaceutical compositions containing such compounds.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | 3-arylquinazoline derivatives as selective estrogen receptor beta modulators |
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