DNA molecules optimized sequences that encode the IA-2IC antigen, RNA molecules, expression vectors, transformed cells, method of preparing the IA-2IC antigen, polypeptide of the human IA-2IC antigen, and in vitro procedure and kit for the diagnosis of autoimmune diabetes

Otimized DNA molecules that encode human IA-2ic, wherein at least one of the codons starting at positions 2747 and 2816 of the complete IA-2 gene is CGT. Said molecules are useful for detecting insulin-dependent (type 1) diabetes mellitus, and may be fused to auxiliary proteins or peptides (for exam...

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