Process for preparing monohydrate and crystal modifications of fluconazole

Process for preparing monohydrate and crystal modifications of fluconazole

A new process is disclosed for the synthesis of fluconazole monohydrate and for crystal modifications of fluconazole which comprises the step of hydrolyzing a silyl ether of the formula (II) wherein R2 is hydrogen, or a C1 to C10 alkyl or phenyl group, R3 and R4 independently of each other are a C1...

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Bibliographische Detailangaben
Hauptverfasser: FARKAS JENONE, PAPP EVA WERKNE, HEGEDUS ISTVAN, BAGDY JUDIT NAGYNE, SZANTAY CSABA, CZIBULA LASZLO, KREIDL NEE REGINA HEGEDUS, LEGAL REPRESENTATIVE JANOSNE, JUHASZ IDA DEUTSCHNE, PILLER AGNES
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:A new process is disclosed for the synthesis of fluconazole monohydrate and for crystal modifications of fluconazole which comprises the step of hydrolyzing a silyl ether of the formula (II) wherein R2 is hydrogen, or a C1 to C10 alkyl or phenyl group, R3 and R4 independently of each other are a C1 to C10 alkyl or phenyl group in an aqueous solution, preferably at a pH below 3 or above 8.