Alpha-amino,-thio,-oxo substituted ketones as phospholipase inhibitors
Inhibitors of the cytosolic phospholypase A2 enzymes are provided which are of use in controlling a wide variety of inflammatory diseases. The inhibitors of the present invention have the general formula wherein X, Z, X1, R1, R2, Ra, Rb, R3, R4 and Y are as defined in the specification.
Gespeichert in:
| Hauptverfasser: | , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | BOUTHILLIER GILLES BALASUBRAMANIAN NEELAKANTAN REMILLARD ROGER BANVILLE JACQUES MARTEL ALAIN |
| description | Inhibitors of the cytosolic phospholypase A2 enzymes are provided which are of use in controlling a wide variety of inflammatory diseases. The inhibitors of the present invention have the general formula wherein X, Z, X1, R1, R2, Ra, Rb, R3, R4 and Y are as defined in the specification. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_US6924391B2</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>US6924391B2</sourcerecordid><originalsourceid>FETCH-epo_espacenet_US6924391B23</originalsourceid><addsrcrecordid>eNqNijEOwjAMALMwIOAPfgAZaBFSx4Ko2IG5csEoFiG2sCvxfDrwAIa7W24eujZrwogvLrKOnniyfARsHMzZR6c7PMmlkAEaaBKbyKxoBFwSD-zytmWYPTAbrX5dBOiOl8MpkkpPpnijQt5fz7um2tbNZl_Vfyxf664zzQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Alpha-amino,-thio,-oxo substituted ketones as phospholipase inhibitors</title><source>esp@cenet</source><creator>BOUTHILLIER GILLES ; BALASUBRAMANIAN NEELAKANTAN ; REMILLARD ROGER ; BANVILLE JACQUES ; MARTEL ALAIN</creator><creatorcontrib>BOUTHILLIER GILLES ; BALASUBRAMANIAN NEELAKANTAN ; REMILLARD ROGER ; BANVILLE JACQUES ; MARTEL ALAIN</creatorcontrib><description>Inhibitors of the cytosolic phospholypase A2 enzymes are provided which are of use in controlling a wide variety of inflammatory diseases. The inhibitors of the present invention have the general formula wherein X, Z, X1, R1, R2, Ra, Rb, R3, R4 and Y are as defined in the specification.</description><edition>7</edition><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2005</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20050802&DB=EPODOC&CC=US&NR=6924391B2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20050802&DB=EPODOC&CC=US&NR=6924391B2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BOUTHILLIER GILLES</creatorcontrib><creatorcontrib>BALASUBRAMANIAN NEELAKANTAN</creatorcontrib><creatorcontrib>REMILLARD ROGER</creatorcontrib><creatorcontrib>BANVILLE JACQUES</creatorcontrib><creatorcontrib>MARTEL ALAIN</creatorcontrib><title>Alpha-amino,-thio,-oxo substituted ketones as phospholipase inhibitors</title><description>Inhibitors of the cytosolic phospholypase A2 enzymes are provided which are of use in controlling a wide variety of inflammatory diseases. The inhibitors of the present invention have the general formula wherein X, Z, X1, R1, R2, Ra, Rb, R3, R4 and Y are as defined in the specification.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2005</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNijEOwjAMALMwIOAPfgAZaBFSx4Ko2IG5csEoFiG2sCvxfDrwAIa7W24eujZrwogvLrKOnniyfARsHMzZR6c7PMmlkAEaaBKbyKxoBFwSD-zytmWYPTAbrX5dBOiOl8MpkkpPpnijQt5fz7um2tbNZl_Vfyxf664zzQ</recordid><startdate>20050802</startdate><enddate>20050802</enddate><creator>BOUTHILLIER GILLES</creator><creator>BALASUBRAMANIAN NEELAKANTAN</creator><creator>REMILLARD ROGER</creator><creator>BANVILLE JACQUES</creator><creator>MARTEL ALAIN</creator><scope>EVB</scope></search><sort><creationdate>20050802</creationdate><title>Alpha-amino,-thio,-oxo substituted ketones as phospholipase inhibitors</title><author>BOUTHILLIER GILLES ; BALASUBRAMANIAN NEELAKANTAN ; REMILLARD ROGER ; BANVILLE JACQUES ; MARTEL ALAIN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US6924391B23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2005</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>BOUTHILLIER GILLES</creatorcontrib><creatorcontrib>BALASUBRAMANIAN NEELAKANTAN</creatorcontrib><creatorcontrib>REMILLARD ROGER</creatorcontrib><creatorcontrib>BANVILLE JACQUES</creatorcontrib><creatorcontrib>MARTEL ALAIN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BOUTHILLIER GILLES</au><au>BALASUBRAMANIAN NEELAKANTAN</au><au>REMILLARD ROGER</au><au>BANVILLE JACQUES</au><au>MARTEL ALAIN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Alpha-amino,-thio,-oxo substituted ketones as phospholipase inhibitors</title><date>2005-08-02</date><risdate>2005</risdate><abstract>Inhibitors of the cytosolic phospholypase A2 enzymes are provided which are of use in controlling a wide variety of inflammatory diseases. The inhibitors of the present invention have the general formula wherein X, Z, X1, R1, R2, Ra, Rb, R3, R4 and Y are as defined in the specification.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng |
| recordid | cdi_epo_espacenet_US6924391B2 |
| source | esp@cenet |
| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | Alpha-amino,-thio,-oxo substituted ketones as phospholipase inhibitors |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T11%3A19%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=BOUTHILLIER%20GILLES&rft.date=2005-08-02&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EUS6924391B2%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |