Triazole compounds useful in treating diseases associated with unwanted cytokine activity

The present invention relates to 4-aryl triazoles having the formula:wherein R is independently selected from the group consisting of: lower alkyl, lower alkenyl, lower alkynyl, lower heteroalkyl, lower heteroalkenyl, lower heteroalkynyl, heterocycloalkyl, heteroaryl, halo, CN, OR , SR , S(O)R , S(O...

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Hauptverfasser: VAN RENS JOHN CHARLES, NATCHUS MICHAEL GEORGE, BLASS BENJAMIN ERIC, TULLIS JOSHUA SPECTOR, CLARK MICHAEL PHILIP, DE BISWANATH
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creator VAN RENS JOHN CHARLES
NATCHUS MICHAEL GEORGE
BLASS BENJAMIN ERIC
TULLIS JOSHUA SPECTOR
CLARK MICHAEL PHILIP
DE BISWANATH
description The present invention relates to 4-aryl triazoles having the formula:wherein R is independently selected from the group consisting of: lower alkyl, lower alkenyl, lower alkynyl, lower heteroalkyl, lower heteroalkenyl, lower heteroalkynyl, heterocycloalkyl, heteroaryl, halo, CN, OR , SR , S(O)R , S(O)2R , and NR R ; and Q is has the general formula:said compounds are useful in treating diseases associated with unwanted cytokine activity, inter alia, interleukin-1 (IL-1) and tumor necrosis factor (TNF) from cells.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Triazole compounds useful in treating diseases associated with unwanted cytokine activity
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