Aromatic sulfone hydroxamic acid metalloprotease inhibitor

A treatment process is disclosed that comprises administering an effective amount of an aromatic sulfone hydroxamic acid that exhibits excellent inhibitory activity of one or more matrix metalloprotease (MMP) enzymes, such as MMP-2, MMP-9 and MMP-13, while exhibiting substantially less inhibition at...

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Hauptverfasser:	FOBIAN YVETTE M, RICO JOSEPH G, BARTA THOMAS E, STEHLE NATHAN W, BECKER DANIEL P, GETMAN DANIEL P, CARROLL JEFFREY N, BOEHM TERRI L, VILLAMIL CLARA I, DECRESCENZO GARY A, MISCHKE DEBORAH A, HOCKERMAN SUSAN L, BEDELL LOUIS J, LI MADELEINE H, FRESKOS JOHN N, VERNIER WILLIAM F, MCDONALD JOSEPH J, KOLODZIEJ STEVE A, TOLLEFSON MICHAEL B, HOWARD SUSAN C
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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