Aromatic sulfone hydroxamic acid metalloprotease inhibitor

Aromatic sulfone hydroxamic acid metalloprotease inhibitor

A treatment process is disclosed that comprises administering an effective amount of an aromatic sulfone hydroxamic acid that exhibits excellent inhibitory activity of one or more matrix metalloprotease (MMP) enzymes, such as MMP-2, MMP-9 and MMP-13, while exhibiting substantially less inhibition at...

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Hauptverfasser: FOBIAN YVETTE M, RICO JOSEPH G, BARTA THOMAS E, STEHLE NATHAN W, BECKER DANIEL P, GETMAN DANIEL P, CARROLL JEFFREY N, BOEHM TERRI L, VILLAMIL CLARA I, DECRESCENZO GARY A, MISCHKE DEBORAH A, HOCKERMAN SUSAN L, BEDELL LOUIS J, LI MADELEINE H, FRESKOS JOHN N, VERNIER WILLIAM F, MCDONALD JOSEPH J, KOLODZIEJ STEVE A, TOLLEFSON MICHAEL B, HOWARD SUSAN C
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:A treatment process is disclosed that comprises administering an effective amount of an aromatic sulfone hydroxamic acid that exhibits excellent inhibitory activity of one or more matrix metalloprotease (MMP) enzymes, such as MMP-2, MMP-9 and MMP-13, while exhibiting substantially less inhibition at least of MMP-1 to a host having a condition associated with pathological matrix metalloprotease activity. Also disclosed are metalloprotease inhibitor compounds having those selective activities, processes for manufacture of such compounds and pharmaceutical compositions using an inhibitor. A contemplated compound corresponds in structure to formula B, below,