Peptidomimetic glutathione analogs

The invention relates to peptidomimetic compounds with formulawherein Z=CH2 and Y=CH2, or Z=O and Y=O=O, which are novel analogs of glutathion and are inhibitors of glutathione S-transferase, in particular of GST P1-1. Such inhibition has beneficial effects in therapy against cancer. In particular c...

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Hauptverfasser:	MULDER GERARD JOHAN, BURG DANNY
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator	MULDER GERARD JOHAN BURG DANNY
description	The invention relates to peptidomimetic compounds with formulawherein Z=CH2 and Y=CH2, or Z=O and Y=O=O, which are novel analogs of glutathion and are inhibitors of glutathione S-transferase, in particular of GST P1-1. Such inhibition has beneficial effects in therapy against cancer. In particular compounds in which R3 is H, R4 is benzyl and R5 is phenyl are stable towards gammaGT activity and are selective for GST P1-1.
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Such inhibition has beneficial effects in therapy against cancer. 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Such inhibition has beneficial effects in therapy against cancer. 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Such inhibition has beneficial effects in therapy against cancer. In particular compounds in which R3 is H, R4 is benzyl and R5 is phenyl are stable towards gammaGT activity and are selective for GST P1-1.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record>
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subjects	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title	Peptidomimetic glutathione analogs
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