Process for preparing guanidine and amidine derivatives

Process for preparing guanidine and amidine derivatives

The invention relates to new compounds of general formula Ior the pharmaceutically acceptable salts thereof, whereinX=N-R3 or CH-R4,Y=CH2 or (CH2)2,Z=O or H2;and R1, R2, R3, R4 and Ar have the meanings given in the specification, and the preparation and use thereof. The new compounds are valuable ne...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: LUETTKE SVEN, MATHES ANDREAS
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention relates to new compounds of general formula Ior the pharmaceutically acceptable salts thereof, whereinX=N-R3 or CH-R4,Y=CH2 or (CH2)2,Z=O or H2;and R1, R2, R3, R4 and Ar have the meanings given in the specification, and the preparation and use thereof. The new compounds are valuable neurokinin (tachykinin) antagonists.