Anticoagulant peptide fragments derived from apolipoprotein B-100

The present invention provides a peptide compound of formula Z1-K-A-Q-X1-K-K-N-K-H-R-H-S-X2-T-Z2 (SEQ ID NO:1) where: X1 represents S or Y, X2 represents T or I, Z1 represents the N terminus of the peptide, or from 1 to 47 amino acids, Z2 represents the C terminus of the peptide, a terminal amide gr...

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Bibliographische Detailangaben
Hauptverfasser:	ETTELAIE CAMILLE, BRUCKDORFER KARL RICHARD
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention provides a peptide compound of formula Z1-K-A-Q-X1-K-K-N-K-H-R-H-S-X2-T-Z2 (SEQ ID NO:1) where: X1 represents S or Y, X2 represents T or I, Z1 represents the N terminus of the peptide, or from 1 to 47 amino acids, Z2 represents the C terminus of the peptide, a terminal amide group, or from 1 to 77 amino acids; or a variant of this peptide which contains one or more internal deletions, insertions or substitutions and which substantially retains anti-coagulant properties of apoB-100.