Histochrome and its therapeutic use in acute myocardial infarction and ischemic heart disease

A pharmaceutical composition is provided, which comprises an aqeous solution containing a mixture of di- and tri-sodium salts of echinochrome in an amount of 0.90 to 1.10 g/ml (Histochrome). It meets the requirements that apply to injectable formulations. Administration of Histochrome reduces by 57%...

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Hauptverfasser: KOLTSOVA EVGENIA ALEXANDROVNA, MISCHENKO NATALYA PETROVNA, ARTJUKOV ALEXANDR ALEXEEVICH, ELYAKOV GEORGY BORISOVICH, MAXIMOV OLEG BORISOVICH, FEDOREEV SERGEI ALEXANDROVICH, KRASOVSKAYA NATALYA PETROVNA, GLEBKO LJUTSIA IGNATIEVNA
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creator KOLTSOVA EVGENIA ALEXANDROVNA
MISCHENKO NATALYA PETROVNA
ARTJUKOV ALEXANDR ALEXEEVICH
ELYAKOV GEORGY BORISOVICH
MAXIMOV OLEG BORISOVICH
FEDOREEV SERGEI ALEXANDROVICH
KRASOVSKAYA NATALYA PETROVNA
GLEBKO LJUTSIA IGNATIEVNA
description A pharmaceutical composition is provided, which comprises an aqeous solution containing a mixture of di- and tri-sodium salts of echinochrome in an amount of 0.90 to 1.10 g/ml (Histochrome). It meets the requirements that apply to injectable formulations. Administration of Histochrome reduces by 57% the necrosis zone in patients with acute myocardial infarction, restores the contractility of the left ventricle, reduces the incidence of reperfusion-induced ventricular arrhythmias and exerts an antiarrhythmogenic effect. Histochrome suppresses the aggregation of erythrocytes and thrombocytes, produces a beneficial effect on the clinical course of the disease, reduces the incidence of complications and lethal outcomes in cases of acute myocardial infarction. It is well tolerated by patients.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Histochrome and its therapeutic use in acute myocardial infarction and ischemic heart disease
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