Treatment of mastitis

The invention provides new fluorinated cephalosporin antibiotics of Formula IwhereinRa, Rb, Rc, Rd and Re, independently, are H, F or a C1-C6 alkyl-(Z)n- group having at least one fluorine substituent;X is O or S;Y is S, O, or -CH2-;Z is O, S, -SO-, or -SO2-;m and n independently are 0 or 1; andR1 i...

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1. Verfasser:	DAHNKE KARL ROBERT
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator	DAHNKE KARL ROBERT
description	The invention provides new fluorinated cephalosporin antibiotics of Formula IwhereinRa, Rb, Rc, Rd and Re, independently, are H, F or a C1-C6 alkyl-(Z)n- group having at least one fluorine substituent;X is O or S;Y is S, O, or -CH2-;Z is O, S, -SO-, or -SO2-;m and n independently are 0 or 1; andR1 is H, C1-C6-alkyl, phenyl or benzyl, each of which may optionally have up to three substituents selected from halo, C1-C4-alkoxy, phenyl, NO2, C1-C6-alkanoyl, benzoyl, or C1-C6-alkanoyloxy; or a physiologically acceptable salt thereof;and methods of preventing or treating or treating infection, particularly mastitis in ruminants, using these antibiotics.
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subjects	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title	Treatment of mastitis
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