Compounds and methods for modulation of estrogen receptors
Compounds that modulate gene expression through the estrogen receptor (ER) are disclosed having the following structure, as well as pharmaceutical compositions containing the same:wherein R1, R2, R3, n and p are as defined here. In a specific embodiment, the compounds are selective modulators for Er...
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| creator | BHAGWAT SHRIPAD S KHAMMUNGKHUNE SAK MCKIE JEFFREY A |
| description | Compounds that modulate gene expression through the estrogen receptor (ER) are disclosed having the following structure, as well as pharmaceutical compositions containing the same:wherein R1, R2, R3, n and p are as defined here. In a specific embodiment, the compounds are selective modulators for Er-beta over ER-alpha. Methods are also disclosed for modulating ER-beta in cells and/or tissues expressing the same, including cells and/or tissues that preferentially express ER-beta. More generally, methods for treating estrogen-related conditions are also disclosed, including conditions such as is breast cancer, testicular cancer, osteoporosis, endometriosis, cardiovascular disease, hypercholesterolemia, prostatic hypertrophy, prostatic carcinomas, obesity, hot flashes, skin effects, mood swings, memory loss, urinary incontinence, hairloss, cataracts, natural hormonal imbalances, and adverse reproductive effects associated with exposure to environmental chemicals. |
| format | Patent |
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In a specific embodiment, the compounds are selective modulators for Er-beta over ER-alpha. Methods are also disclosed for modulating ER-beta in cells and/or tissues expressing the same, including cells and/or tissues that preferentially express ER-beta. More generally, methods for treating estrogen-related conditions are also disclosed, including conditions such as is breast cancer, testicular cancer, osteoporosis, endometriosis, cardiovascular disease, hypercholesterolemia, prostatic hypertrophy, prostatic carcinomas, obesity, hot flashes, skin effects, mood swings, memory loss, urinary incontinence, hairloss, cataracts, natural hormonal imbalances, and adverse reproductive effects associated with exposure to environmental chemicals.</description><edition>7</edition><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2001</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20011218&DB=EPODOC&CC=US&NR=6331562B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20011218&DB=EPODOC&CC=US&NR=6331562B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BHAGWAT SHRIPAD S</creatorcontrib><creatorcontrib>KHAMMUNGKHUNE SAK</creatorcontrib><creatorcontrib>MCKIE JEFFREY A</creatorcontrib><title>Compounds and methods for modulation of estrogen receptors</title><description>Compounds that modulate gene expression through the estrogen receptor (ER) are disclosed having the following structure, as well as pharmaceutical compositions containing the same:wherein R1, R2, R3, n and p are as defined here. In a specific embodiment, the compounds are selective modulators for Er-beta over ER-alpha. Methods are also disclosed for modulating ER-beta in cells and/or tissues expressing the same, including cells and/or tissues that preferentially express ER-beta. More generally, methods for treating estrogen-related conditions are also disclosed, including conditions such as is breast cancer, testicular cancer, osteoporosis, endometriosis, cardiovascular disease, hypercholesterolemia, prostatic hypertrophy, prostatic carcinomas, obesity, hot flashes, skin effects, mood swings, memory loss, urinary incontinence, hairloss, cataracts, natural hormonal imbalances, and adverse reproductive effects associated with exposure to environmental chemicals.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2001</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLByzs8tyC_NSylWSMxLUchNLcnIB7LT8osUcvNTSnMSSzLz8xTy0xRSi0uK8tNT8xSKUpNTC0ryi4p5GFjTEnOKU3mhNDeDgptriLOHbmpBfnxqcUFicmpeakl8aLCZsbGhqZmRk6ExEUoATHAvOg</recordid><startdate>20011218</startdate><enddate>20011218</enddate><creator>BHAGWAT SHRIPAD S</creator><creator>KHAMMUNGKHUNE SAK</creator><creator>MCKIE JEFFREY A</creator><scope>EVB</scope></search><sort><creationdate>20011218</creationdate><title>Compounds and methods for modulation of estrogen receptors</title><author>BHAGWAT SHRIPAD S ; KHAMMUNGKHUNE SAK ; MCKIE JEFFREY A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US6331562B13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2001</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>BHAGWAT SHRIPAD S</creatorcontrib><creatorcontrib>KHAMMUNGKHUNE SAK</creatorcontrib><creatorcontrib>MCKIE JEFFREY A</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BHAGWAT SHRIPAD S</au><au>KHAMMUNGKHUNE SAK</au><au>MCKIE JEFFREY A</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Compounds and methods for modulation of estrogen receptors</title><date>2001-12-18</date><risdate>2001</risdate><abstract>Compounds that modulate gene expression through the estrogen receptor (ER) are disclosed having the following structure, as well as pharmaceutical compositions containing the same:wherein R1, R2, R3, n and p are as defined here. In a specific embodiment, the compounds are selective modulators for Er-beta over ER-alpha. Methods are also disclosed for modulating ER-beta in cells and/or tissues expressing the same, including cells and/or tissues that preferentially express ER-beta. More generally, methods for treating estrogen-related conditions are also disclosed, including conditions such as is breast cancer, testicular cancer, osteoporosis, endometriosis, cardiovascular disease, hypercholesterolemia, prostatic hypertrophy, prostatic carcinomas, obesity, hot flashes, skin effects, mood swings, memory loss, urinary incontinence, hairloss, cataracts, natural hormonal imbalances, and adverse reproductive effects associated with exposure to environmental chemicals.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Compounds and methods for modulation of estrogen receptors |
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