Apparatus and method for inducing epileptic seizures in test animals for anticonvulsant drug screening

Apparatus and method for inducing epileptic seizures in test animals for anticonvulsant drug screening

A stimulator for electrically inducing a maximal seizure in a test animal for screening candidate anticonvulsant drugs is disclosed. A stimulator according to this invention includes stimulus generation and control circuitry for generating the stimulus, a display for displaying the duration of three...

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Hauptverfasser: RAINEY ROBERT R, JONES GARY L
Format: Patent
Sprache:eng
Schlagworte:
ELECTROTHERAPY
HUMAN NECESSITIES
HYGIENE
MAGNETOTHERAPY
MEDICAL OR VETERINARY SCIENCE
RADIATION THERAPY
ULTRASOUND THERAPY
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creator RAINEY ROBERT R
JONES GARY L
description A stimulator for electrically inducing a maximal seizure in a test animal for screening candidate anticonvulsant drugs is disclosed. A stimulator according to this invention includes stimulus generation and control circuitry for generating the stimulus, a display for displaying the duration of three phases of the induced seizure, and user input configured to allow the user to control delivery of the stimulus and to record seizure phase transitions to be displayed on the display. The stimulator may also include a foot switch, electrodes, a computer interface and an optional computer. A method of measuring the phases of an electrically induced seizure is disclosed. A method of analyzing the efficacy of a candidate anticonvulsant drug is also disclosed.
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subjects ELECTROTHERAPY
HUMAN NECESSITIES
HYGIENE
MAGNETOTHERAPY
MEDICAL OR VETERINARY SCIENCE
RADIATION THERAPY
ULTRASOUND THERAPY
title Apparatus and method for inducing epileptic seizures in test animals for anticonvulsant drug screening
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