Method for synthesizing labelled compounds

A process and a device for synthesizing labeled compounds. The process involves preparing a labeling agent, labeling a precursor with the labeling agent, where the precursor is a protected substrate, and deprotecting the labeled precursor to convert the labeled precursor to a labeled compound by pas...

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Hauptverfasser: MONCLUS MICHEL, LEMAIRE CHRISTIAN F, DAMHAUT PHILIPPE E, VAN NAMEN JOHN J, MORELLE JEAN-LUC E, MULLENEERS ERIC, LUXEN ANDRE, LAURICELLA BENJAMIN P
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creator MONCLUS MICHEL
LEMAIRE CHRISTIAN F
DAMHAUT PHILIPPE E
VAN NAMEN JOHN J
MORELLE JEAN-LUC E
MULLENEERS ERIC
LUXEN ANDRE
LAURICELLA BENJAMIN P
description A process and a device for synthesizing labeled compounds. The process involves preparing a labeling agent, labeling a precursor with the labeling agent, where the precursor is a protected substrate, and deprotecting the labeled precursor to convert the labeled precursor to a labeled compound by passing the labeled precursor through a solid support in a column or a cartridge. The process may be used to convert labeled tetraacetylfluoroglucose (TAFg) to labeled fluoro-deoxy-glucose (FDG) for use in nuclear medical imaging. The process is more rapid than conventional methods and is performed at room temperature rather than high temperature for conventional technology.
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subjects APPARATUS THEREFOR
CHEMISTRY
DERIVATIVES THEREOF
GENERAL METHODS OF ORGANIC CHEMISTRY
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
title Method for synthesizing labelled compounds
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