Processes for making and using alkylaminoarylcarbonyl compounds

Processes for making and using alkylaminoarylcarbonyl compounds

A method of making an alkylaminoarylcarbonyl compound having Formula I: wherein R is an alkyl group; A is an aryl (including heteroaryl) ring; each R' is independently an alkyl group which may form a ring with Z or Z'; p is 0, 1, 2, or 3; each Z, Z', and Y is independently hydrogen or...

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Hauptverfasser: MOOBERRY, JARED B, SEIFERT, JAMES J, KIM, CHANG-KYU, HOKE, DAVID
Format: Patent
Sprache:eng
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ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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creator MOOBERRY
JARED B
SEIFERT
JAMES J
KIM
CHANG-KYU
HOKE
DAVID
description A method of making an alkylaminoarylcarbonyl compound having Formula I: wherein R is an alkyl group; A is an aryl (including heteroaryl) ring; each R' is independently an alkyl group which may form a ring with Z or Z'; p is 0, 1, 2, or 3; each Z, Z', and Y is independently hydrogen or a substituent; and n is 0, 1, or 2; comprising: (a) blocking the carbonyl function of an aminoarylcarbonyl compound via condensation with an active methylene compound (b) alkylating this blocked amniocarbonyl compound via reductive alkylation with an alkyl or aryl (including heteroaryl) carbonyl compound, and (c) deblocking of the blocked alkylaminoarylcarbonyl compound via base hydrolysis to regenerate the carbonyl function and give the desired alkylaminocarbonyl compound.
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subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
title Processes for making and using alkylaminoarylcarbonyl compounds
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