Inhibitors of farnesyl-protein transferase

Inhibitors of farnesyl-protein transferase

The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-prote...

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Hauptverfasser: ANTHONY, NEVILLE J, TRAN, LEKHANH O, YOUNG, STEVEN D, GOMEZ, ROBERT P
Format: Patent
Sprache:eng
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator ANTHONY
NEVILLE J
TRAN
LEKHANH O
YOUNG
STEVEN D
GOMEZ
ROBERT P
description The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title Inhibitors of farnesyl-protein transferase
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