Monoclonal antibodies reactive with defined regions of the T cell antigen receptor
The present invention relates to monoclonal antibodies which recognize defined regions of the T-cell receptor (TCR). In a specific embodiment, the invention provides monoclonal antibodies which are reactive with a constant region of the alpha chain of the TCR. In particular embodiments, the inventio...
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| creator | IP STEPHEN H KO JONE-LONG SKIBBENS ROBERT V SNIDER MARY ELLEN TIAN WEI-TAO KUNG PATRICK C HENRY LARRY D RITTERSHAUS CHARLES W WOOD NANCY L |
| description | The present invention relates to monoclonal antibodies which recognize defined regions of the T-cell receptor (TCR). In a specific embodiment, the invention provides monoclonal antibodies which are reactive with a constant region of the alpha chain of the TCR. In particular embodiments, the invention relates to two monoclonal antibodies, termed alpha F1 and alpha F2, which react with two different epitopes on the framework region of the alpha monomer of the TCR molecule. In another specific embodiment, the invention is directed to monoclonal antibodies reactive with a variable region of the beta chain of the TCR. In particular, the invention provides two monoclonal antibodies, termed W112 and 2D1, which react with beta chain variable regions V beta 5.3 and V beta 8.1, respectively. In another specific embodiment, the invention is directed to monoclonal antibodies reactive with a variable region of the delta chain of the TCR. In particular, the invention provides monoclonal antibody delta TCS1, isotype IgG2a. The monoclonal antibodies of the invention have value in diagnosis and therapy and are useful tools for study of the immune system. |
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| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_US5980892A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>US5980892A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_US5980892A3</originalsourceid><addsrcrecordid>eNqFi7EKwjAURbM4iPoNvh8QRBHasYji4qJ1LjG5aQPhvdA89Pct6O504Zxz5-Z2FRaXhG0iyxqf4iMKjbBO4wv0jjqQR4gMP9E-CheSQDqAWnJI31sPnqxDVhmXZhZsKlj9dmHW51N7vGyQpUPJ1oGh3eN-qKttVe-a_f_iA0ixN3I</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Monoclonal antibodies reactive with defined regions of the T cell antigen receptor</title><source>esp@cenet</source><creator>IP; STEPHEN H ; KO; JONE-LONG ; SKIBBENS; ROBERT V ; SNIDER; MARY ELLEN ; TIAN; WEI-TAO ; KUNG; PATRICK C ; HENRY; LARRY D ; RITTERSHAUS; CHARLES W ; WOOD; NANCY L</creator><creatorcontrib>IP; STEPHEN H ; KO; JONE-LONG ; SKIBBENS; ROBERT V ; SNIDER; MARY ELLEN ; TIAN; WEI-TAO ; KUNG; PATRICK C ; HENRY; LARRY D ; RITTERSHAUS; CHARLES W ; WOOD; NANCY L</creatorcontrib><description>The present invention relates to monoclonal antibodies which recognize defined regions of the T-cell receptor (TCR). In a specific embodiment, the invention provides monoclonal antibodies which are reactive with a constant region of the alpha chain of the TCR. In particular embodiments, the invention relates to two monoclonal antibodies, termed alpha F1 and alpha F2, which react with two different epitopes on the framework region of the alpha monomer of the TCR molecule. In another specific embodiment, the invention is directed to monoclonal antibodies reactive with a variable region of the beta chain of the TCR. In particular, the invention provides two monoclonal antibodies, termed W112 and 2D1, which react with beta chain variable regions V beta 5.3 and V beta 8.1, respectively. In another specific embodiment, the invention is directed to monoclonal antibodies reactive with a variable region of the delta chain of the TCR. In particular, the invention provides monoclonal antibody delta TCS1, isotype IgG2a. The monoclonal antibodies of the invention have value in diagnosis and therapy and are useful tools for study of the immune system.</description><edition>6</edition><language>eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; HUMAN NECESSITIES ; HYGIENE ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PHYSICS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROCESSES USING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; TESTING ; VINEGAR ; WINE</subject><creationdate>1999</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19991109&DB=EPODOC&CC=US&NR=5980892A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19991109&DB=EPODOC&CC=US&NR=5980892A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>IP; STEPHEN H</creatorcontrib><creatorcontrib>KO; JONE-LONG</creatorcontrib><creatorcontrib>SKIBBENS; ROBERT V</creatorcontrib><creatorcontrib>SNIDER; MARY ELLEN</creatorcontrib><creatorcontrib>TIAN; WEI-TAO</creatorcontrib><creatorcontrib>KUNG; PATRICK C</creatorcontrib><creatorcontrib>HENRY; LARRY D</creatorcontrib><creatorcontrib>RITTERSHAUS; CHARLES W</creatorcontrib><creatorcontrib>WOOD; NANCY L</creatorcontrib><title>Monoclonal antibodies reactive with defined regions of the T cell antigen receptor</title><description>The present invention relates to monoclonal antibodies which recognize defined regions of the T-cell receptor (TCR). In a specific embodiment, the invention provides monoclonal antibodies which are reactive with a constant region of the alpha chain of the TCR. In particular embodiments, the invention relates to two monoclonal antibodies, termed alpha F1 and alpha F2, which react with two different epitopes on the framework region of the alpha monomer of the TCR molecule. In another specific embodiment, the invention is directed to monoclonal antibodies reactive with a variable region of the beta chain of the TCR. In particular, the invention provides two monoclonal antibodies, termed W112 and 2D1, which react with beta chain variable regions V beta 5.3 and V beta 8.1, respectively. In another specific embodiment, the invention is directed to monoclonal antibodies reactive with a variable region of the delta chain of the TCR. In particular, the invention provides monoclonal antibody delta TCS1, isotype IgG2a. The monoclonal antibodies of the invention have value in diagnosis and therapy and are useful tools for study of the immune system.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PHYSICS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROCESSES USING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>TESTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1999</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqFi7EKwjAURbM4iPoNvh8QRBHasYji4qJ1LjG5aQPhvdA89Pct6O504Zxz5-Z2FRaXhG0iyxqf4iMKjbBO4wv0jjqQR4gMP9E-CheSQDqAWnJI31sPnqxDVhmXZhZsKlj9dmHW51N7vGyQpUPJ1oGh3eN-qKttVe-a_f_iA0ixN3I</recordid><startdate>19991109</startdate><enddate>19991109</enddate><creator>IP; STEPHEN H</creator><creator>KO; JONE-LONG</creator><creator>SKIBBENS; ROBERT V</creator><creator>SNIDER; MARY ELLEN</creator><creator>TIAN; WEI-TAO</creator><creator>KUNG; PATRICK C</creator><creator>HENRY; LARRY D</creator><creator>RITTERSHAUS; CHARLES W</creator><creator>WOOD; NANCY L</creator><scope>EVB</scope></search><sort><creationdate>19991109</creationdate><title>Monoclonal antibodies reactive with defined regions of the T cell antigen receptor</title><author>IP; STEPHEN H ; KO; JONE-LONG ; SKIBBENS; ROBERT V ; SNIDER; MARY ELLEN ; TIAN; WEI-TAO ; KUNG; PATRICK C ; HENRY; LARRY D ; RITTERSHAUS; CHARLES W ; WOOD; NANCY L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US5980892A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1999</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>ENZYMOLOGY</topic><topic>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PHYSICS</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROCESSES USING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>TESTING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>IP; STEPHEN H</creatorcontrib><creatorcontrib>KO; JONE-LONG</creatorcontrib><creatorcontrib>SKIBBENS; ROBERT V</creatorcontrib><creatorcontrib>SNIDER; MARY ELLEN</creatorcontrib><creatorcontrib>TIAN; WEI-TAO</creatorcontrib><creatorcontrib>KUNG; PATRICK C</creatorcontrib><creatorcontrib>HENRY; LARRY D</creatorcontrib><creatorcontrib>RITTERSHAUS; CHARLES W</creatorcontrib><creatorcontrib>WOOD; NANCY L</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>IP; STEPHEN H</au><au>KO; JONE-LONG</au><au>SKIBBENS; ROBERT V</au><au>SNIDER; MARY ELLEN</au><au>TIAN; WEI-TAO</au><au>KUNG; PATRICK C</au><au>HENRY; LARRY D</au><au>RITTERSHAUS; CHARLES W</au><au>WOOD; NANCY L</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Monoclonal antibodies reactive with defined regions of the T cell antigen receptor</title><date>1999-11-09</date><risdate>1999</risdate><abstract>The present invention relates to monoclonal antibodies which recognize defined regions of the T-cell receptor (TCR). In a specific embodiment, the invention provides monoclonal antibodies which are reactive with a constant region of the alpha chain of the TCR. In particular embodiments, the invention relates to two monoclonal antibodies, termed alpha F1 and alpha F2, which react with two different epitopes on the framework region of the alpha monomer of the TCR molecule. In another specific embodiment, the invention is directed to monoclonal antibodies reactive with a variable region of the beta chain of the TCR. In particular, the invention provides two monoclonal antibodies, termed W112 and 2D1, which react with beta chain variable regions V beta 5.3 and V beta 8.1, respectively. In another specific embodiment, the invention is directed to monoclonal antibodies reactive with a variable region of the delta chain of the TCR. In particular, the invention provides monoclonal antibody delta TCS1, isotype IgG2a. The monoclonal antibodies of the invention have value in diagnosis and therapy and are useful tools for study of the immune system.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE |
| title | Monoclonal antibodies reactive with defined regions of the T cell antigen receptor |
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