Labeled chemotactic peptides to image focal sites of infection or inflammation
The invention relates to a method of detecting a site of infection or inflammation, and a method for treating such infection or inflammation, in an individual by administering to the individual a diagnostically or therapeutically effective amount of detectably labeled, therapeutic, or therapeuticall...
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| creator | FUCCELLO ANTHONY J RUBIN ROBERT H KROON DANIEL J HERNANDEZ PEDRO E HIGGINS, III JOHN D LARSEN SCOTT K FISCHMAN ALAN J DERIAN CLAUDIA K BRIDGER GARY J STRAUSS H. WILLIAM SOLOMON HOWARD F |
| description | The invention relates to a method of detecting a site of infection or inflammation, and a method for treating such infection or inflammation, in an individual by administering to the individual a diagnostically or therapeutically effective amount of detectably labeled, therapeutic, or therapeutically-conjugated, chemotactic peptide that accumulates substantially at the infected or inflamed site, said chemotactic peptide having the general structureX-Y-Leu-Phe-[Z]n-Wwherein: X is an amino protecting group, Y is an amino acid residue, Z is a spacer sequence, n is 0 or 1, and W is a labeling or attachment substituent. |
| format | Patent |
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WILLIAM ; SOLOMON; HOWARD F</creatorcontrib><description>The invention relates to a method of detecting a site of infection or inflammation, and a method for treating such infection or inflammation, in an individual by administering to the individual a diagnostically or therapeutically effective amount of detectably labeled, therapeutic, or therapeutically-conjugated, chemotactic peptide that accumulates substantially at the infected or inflamed site, said chemotactic peptide having the general structureX-Y-Leu-Phe-[Z]n-Wwherein: X is an amino protecting group, Y is an amino acid residue, Z is a spacer sequence, n is 0 or 1, and W is a labeling or attachment substituent.</description><edition>6</edition><language>eng</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1998</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19980811&DB=EPODOC&CC=US&NR=5792444A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25569,76552</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19980811&DB=EPODOC&CC=US&NR=5792444A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>FUCCELLO; ANTHONY J</creatorcontrib><creatorcontrib>RUBIN; ROBERT H</creatorcontrib><creatorcontrib>KROON; DANIEL J</creatorcontrib><creatorcontrib>HERNANDEZ; PEDRO E</creatorcontrib><creatorcontrib>HIGGINS, III; JOHN D</creatorcontrib><creatorcontrib>LARSEN; SCOTT K</creatorcontrib><creatorcontrib>FISCHMAN; ALAN J</creatorcontrib><creatorcontrib>DERIAN; CLAUDIA K</creatorcontrib><creatorcontrib>BRIDGER; GARY J</creatorcontrib><creatorcontrib>STRAUSS; H. 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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Labeled chemotactic peptides to image focal sites of infection or inflammation |
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