Process for preparing N-phenyl-N-methoxyacetyl-DL-alanine methyl ester derivatives
Process for the preparation of N-phenyl-N-methoxyacetyl-DL-alanine methyl ester derivatives of the formula (I). (I) wherein R is a C1-4 alkyl residue; and n is a cardinal number between from 1 to 3, which comprises reacting an N-methoxyacetyl derivative of the formula (II). (II) wherein R and n are...
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| creator | SOEPTEI CSABA KOLONICS ZOLTAN KRANITZ TIBOR LEGRADI LASZLO AGOCS PAL BENCZIK JUDIT SEBOK DEZSO CSEKE JOLAN NAGY LAJOS BALINT SANDOR PELYVA JENO |
| description | Process for the preparation of N-phenyl-N-methoxyacetyl-DL-alanine methyl ester derivatives of the formula (I). (I) wherein R is a C1-4 alkyl residue; and n is a cardinal number between from 1 to 3, which comprises reacting an N-methoxyacetyl derivative of the formula (II). (II) wherein R and n are as defined above, with a stoichiometric amount of an alkaline metal alkoxide, at a temperature between 80 DEG C. and 150 DEG C., until completion of the removal of the alkanol present in the system, then reacting the thus obtained alkaline metal salt of the compound of formula (II) directly or after isolation with a methyl DL-x-halopropionate. |
| format | Patent |
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(I) wherein R is a C1-4 alkyl residue; and n is a cardinal number between from 1 to 3, which comprises reacting an N-methoxyacetyl derivative of the formula (II). (II) wherein R and n are as defined above, with a stoichiometric amount of an alkaline metal alkoxide, at a temperature between 80 DEG C. and 150 DEG C., until completion of the removal of the alkanol present in the system, then reacting the thus obtained alkaline metal salt of the compound of formula (II) directly or after isolation with a methyl DL-x-halopropionate.</description><edition>6</edition><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>1997</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19970617&DB=EPODOC&CC=US&NR=5639905A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25568,76551</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19970617&DB=EPODOC&CC=US&NR=5639905A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SOEPTEI; CSABA</creatorcontrib><creatorcontrib>KOLONICS; ZOLTAN</creatorcontrib><creatorcontrib>KRANITZ; TIBOR</creatorcontrib><creatorcontrib>LEGRADI; LASZLO</creatorcontrib><creatorcontrib>AGOCS; PAL</creatorcontrib><creatorcontrib>BENCZIK JUDIT</creatorcontrib><creatorcontrib>SEBOK; DEZSO</creatorcontrib><creatorcontrib>CSEKE; JOLAN</creatorcontrib><creatorcontrib>NAGY; LAJOS</creatorcontrib><creatorcontrib>BALINT; SANDOR</creatorcontrib><creatorcontrib>PELYVA; JENO</creatorcontrib><title>Process for preparing N-phenyl-N-methoxyacetyl-DL-alanine methyl ester derivatives</title><description>Process for the preparation of N-phenyl-N-methoxyacetyl-DL-alanine methyl ester derivatives of the formula (I). (I) wherein R is a C1-4 alkyl residue; and n is a cardinal number between from 1 to 3, which comprises reacting an N-methoxyacetyl derivative of the formula (II). 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(I) wherein R is a C1-4 alkyl residue; and n is a cardinal number between from 1 to 3, which comprises reacting an N-methoxyacetyl derivative of the formula (II). (II) wherein R and n are as defined above, with a stoichiometric amount of an alkaline metal alkoxide, at a temperature between 80 DEG C. and 150 DEG C., until completion of the removal of the alkanol present in the system, then reacting the thus obtained alkaline metal salt of the compound of formula (II) directly or after isolation with a methyl DL-x-halopropionate.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| title | Process for preparing N-phenyl-N-methoxyacetyl-DL-alanine methyl ester derivatives |
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