Process for preparing N-phenyl-N-methoxyacetyl-DL-alanine methyl ester derivatives

Process for preparing N-phenyl-N-methoxyacetyl-DL-alanine methyl ester derivatives

Process for the preparation of N-phenyl-N-methoxyacetyl-DL-alanine methyl ester derivatives of the formula (I). (I) wherein R is a C1-4 alkyl residue; and n is a cardinal number between from 1 to 3, which comprises reacting an N-methoxyacetyl derivative of the formula (II). (II) wherein R and n are...

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Bibliographische Detailangaben
Hauptverfasser: SOEPTEI, CSABA, KOLONICS, ZOLTAN, KRANITZ, TIBOR, LEGRADI, LASZLO, AGOCS, PAL, BENCZIK JUDIT, SEBOK, DEZSO, CSEKE, JOLAN, NAGY, LAJOS, BALINT, SANDOR, PELYVA, JENO
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:Process for the preparation of N-phenyl-N-methoxyacetyl-DL-alanine methyl ester derivatives of the formula (I). (I) wherein R is a C1-4 alkyl residue; and n is a cardinal number between from 1 to 3, which comprises reacting an N-methoxyacetyl derivative of the formula (II). (II) wherein R and n are as defined above, with a stoichiometric amount of an alkaline metal alkoxide, at a temperature between 80 DEG C. and 150 DEG C., until completion of the removal of the alkanol present in the system, then reacting the thus obtained alkaline metal salt of the compound of formula (II) directly or after isolation with a methyl DL-x-halopropionate.