Pharmaceutical use of pyridine compounds
A pyridine compound of the formula (I) wherein R1 is a hydrogen, a halogen, an alkyl, an alkoxy or the like, R2 and R3 are each a hydrogen, a halogen or an alkyl, -P=Q- is -CH=CH-, -N=CH- or -CH=N-, A is an oxygen atom, a sulfur atom or N(R4) wherein R4 is hydrogen, alkyl or the like, n is 0, 1 or 2...
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| creator | KAWAKITA TAKESHI HAGA KEIICHIRO YUTOKU YUKO SANO MITSUHARU IKEDA YOSHIFUMI |
| description | A pyridine compound of the formula (I) wherein R1 is a hydrogen, a halogen, an alkyl, an alkoxy or the like, R2 and R3 are each a hydrogen, a halogen or an alkyl, -P=Q- is -CH=CH-, -N=CH- or -CH=N-, A is an oxygen atom, a sulfur atom or N(R4) wherein R4 is hydrogen, alkyl or the like, n is 0, 1 or 2, B is S(O)p wherein p is 0, 1 or 2, D is a single bond, an alkylene or the like and E is an alkoxyalkyl or -N(R6)(R7), and a pharmaceutically acceptable salt thereof have antibacterial activity against Helicobacter pylori, antiulcer activity, gastrointestinal cytoprotective activity, ulcer recurrence, relapse-preventive activity and gastric acid secretion-suppressive activity and are useful as pharmaceutical preparations.
A pyridine compound of the formula (I) wherein R1 is a hydrogen, a halogen, an alkyl, an alkoxy or the like, R2 and R3 are each a hydrogen, a halogen or an alkyl, -P=Q- is -CH=CH-, -N=CH- or -CH=N-, A is an oxygen atom, a sulfur atom or N(R4) wherein R4 is hydrogen, alkyl or the like, n is 0, 1 or 2, B is S(O)p wherein p is 0, 1 or 2, D is a single bond, an alkylene or the like and E is an alkoxyalkyl or -N(R6)(R7), and a pharmaceutically acceptable salt thereof have antibacterial activity against Helicobacter pylori, antiulcer activity, gastrointestinal cytoprotective activity, ulcer recurrence, relapse-preventive activity and gastric acid secretion-suppressive activity and are useful as pharmaceutical preparations. |
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A pyridine compound of the formula (I) wherein R1 is a hydrogen, a halogen, an alkyl, an alkoxy or the like, R2 and R3 are each a hydrogen, a halogen or an alkyl, -P=Q- is -CH=CH-, -N=CH- or -CH=N-, A is an oxygen atom, a sulfur atom or N(R4) wherein R4 is hydrogen, alkyl or the like, n is 0, 1 or 2, B is S(O)p wherein p is 0, 1 or 2, D is a single bond, an alkylene or the like and E is an alkoxyalkyl or -N(R6)(R7), and a pharmaceutically acceptable salt thereof have antibacterial activity against Helicobacter pylori, antiulcer activity, gastrointestinal cytoprotective activity, ulcer recurrence, relapse-preventive activity and gastric acid secretion-suppressive activity and are useful as pharmaceutical preparations.</description><edition>6</edition><language>eng</language><subject>CHEMISTRY ; COMPOSITIONS BASED THEREON ; HETEROCYCLIC COMPOUNDS ; MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS ; METALLURGY ; ORGANIC CHEMISTRY ; ORGANIC MACROMOLECULAR COMPOUNDS ; THEIR PREPARATION OR CHEMICAL WORKING-UP</subject><creationdate>1997</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19970401&DB=EPODOC&CC=US&NR=5616581A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19970401&DB=EPODOC&CC=US&NR=5616581A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KAWAKITA; TAKESHI</creatorcontrib><creatorcontrib>HAGA; KEIICHIRO</creatorcontrib><creatorcontrib>YUTOKU; YUKO</creatorcontrib><creatorcontrib>SANO; MITSUHARU</creatorcontrib><creatorcontrib>IKEDA; YOSHIFUMI</creatorcontrib><title>Pharmaceutical use of pyridine compounds</title><description>A pyridine compound of the formula (I) wherein R1 is a hydrogen, a halogen, an alkyl, an alkoxy or the like, R2 and R3 are each a hydrogen, a halogen or an alkyl, -P=Q- is -CH=CH-, -N=CH- or -CH=N-, A is an oxygen atom, a sulfur atom or N(R4) wherein R4 is hydrogen, alkyl or the like, n is 0, 1 or 2, B is S(O)p wherein p is 0, 1 or 2, D is a single bond, an alkylene or the like and E is an alkoxyalkyl or -N(R6)(R7), and a pharmaceutically acceptable salt thereof have antibacterial activity against Helicobacter pylori, antiulcer activity, gastrointestinal cytoprotective activity, ulcer recurrence, relapse-preventive activity and gastric acid secretion-suppressive activity and are useful as pharmaceutical preparations.
A pyridine compound of the formula (I) wherein R1 is a hydrogen, a halogen, an alkyl, an alkoxy or the like, R2 and R3 are each a hydrogen, a halogen or an alkyl, -P=Q- is -CH=CH-, -N=CH- or -CH=N-, A is an oxygen atom, a sulfur atom or N(R4) wherein R4 is hydrogen, alkyl or the like, n is 0, 1 or 2, B is S(O)p wherein p is 0, 1 or 2, D is a single bond, an alkylene or the like and E is an alkoxyalkyl or -N(R6)(R7), and a pharmaceutically acceptable salt thereof have antibacterial activity against Helicobacter pylori, antiulcer activity, gastrointestinal cytoprotective activity, ulcer recurrence, relapse-preventive activity and gastric acid secretion-suppressive activity and are useful as pharmaceutical preparations.</description><subject>CHEMISTRY</subject><subject>COMPOSITIONS BASED THEREON</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>ORGANIC MACROMOLECULAR COMPOUNDS</subject><subject>THEIR PREPARATION OR CHEMICAL WORKING-UP</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1997</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNAIyEgsyk1MTi0tyUxOzFEoLU5VyE9TKKgsykzJzEtVSM7PLcgvzUsp5mFgTUvMKU7lhdLcDPJuriHOHrqpBfnxqcUFQCPyUkviQ4NNzQzNTC0MHY0JqwAAVrQn-g</recordid><startdate>19970401</startdate><enddate>19970401</enddate><creator>KAWAKITA; TAKESHI</creator><creator>HAGA; KEIICHIRO</creator><creator>YUTOKU; YUKO</creator><creator>SANO; MITSUHARU</creator><creator>IKEDA; YOSHIFUMI</creator><scope>EVB</scope></search><sort><creationdate>19970401</creationdate><title>Pharmaceutical use of pyridine compounds</title><author>KAWAKITA; TAKESHI ; HAGA; KEIICHIRO ; YUTOKU; YUKO ; SANO; MITSUHARU ; IKEDA; YOSHIFUMI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US5616581A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1997</creationdate><topic>CHEMISTRY</topic><topic>COMPOSITIONS BASED THEREON</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>ORGANIC MACROMOLECULAR COMPOUNDS</topic><topic>THEIR PREPARATION OR CHEMICAL WORKING-UP</topic><toplevel>online_resources</toplevel><creatorcontrib>KAWAKITA; TAKESHI</creatorcontrib><creatorcontrib>HAGA; KEIICHIRO</creatorcontrib><creatorcontrib>YUTOKU; YUKO</creatorcontrib><creatorcontrib>SANO; MITSUHARU</creatorcontrib><creatorcontrib>IKEDA; YOSHIFUMI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KAWAKITA; TAKESHI</au><au>HAGA; KEIICHIRO</au><au>YUTOKU; YUKO</au><au>SANO; MITSUHARU</au><au>IKEDA; YOSHIFUMI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Pharmaceutical use of pyridine compounds</title><date>1997-04-01</date><risdate>1997</risdate><abstract>A pyridine compound of the formula (I) wherein R1 is a hydrogen, a halogen, an alkyl, an alkoxy or the like, R2 and R3 are each a hydrogen, a halogen or an alkyl, -P=Q- is -CH=CH-, -N=CH- or -CH=N-, A is an oxygen atom, a sulfur atom or N(R4) wherein R4 is hydrogen, alkyl or the like, n is 0, 1 or 2, B is S(O)p wherein p is 0, 1 or 2, D is a single bond, an alkylene or the like and E is an alkoxyalkyl or -N(R6)(R7), and a pharmaceutically acceptable salt thereof have antibacterial activity against Helicobacter pylori, antiulcer activity, gastrointestinal cytoprotective activity, ulcer recurrence, relapse-preventive activity and gastric acid secretion-suppressive activity and are useful as pharmaceutical preparations.
A pyridine compound of the formula (I) wherein R1 is a hydrogen, a halogen, an alkyl, an alkoxy or the like, R2 and R3 are each a hydrogen, a halogen or an alkyl, -P=Q- is -CH=CH-, -N=CH- or -CH=N-, A is an oxygen atom, a sulfur atom or N(R4) wherein R4 is hydrogen, alkyl or the like, n is 0, 1 or 2, B is S(O)p wherein p is 0, 1 or 2, D is a single bond, an alkylene or the like and E is an alkoxyalkyl or -N(R6)(R7), and a pharmaceutically acceptable salt thereof have antibacterial activity against Helicobacter pylori, antiulcer activity, gastrointestinal cytoprotective activity, ulcer recurrence, relapse-preventive activity and gastric acid secretion-suppressive activity and are useful as pharmaceutical preparations.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY COMPOSITIONS BASED THEREON HETEROCYCLIC COMPOUNDS MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS METALLURGY ORGANIC CHEMISTRY ORGANIC MACROMOLECULAR COMPOUNDS THEIR PREPARATION OR CHEMICAL WORKING-UP |
| title | Pharmaceutical use of pyridine compounds |
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