Process for the preparation of N-(2-sulfatoethyl)-piperazine in high purity

A process for the preparation of N-(2-sulfatoethyl)-piperazine in high purity, which comprises reacting N-(2-hydroxyethyl)piperazine in a mixture of highly-or relatively highly-concentrated sulfuric acid and oleum or chlorosulfonic acid at temperatures of from about 80 DEG to about 250 DEG C., transferring the resulting sulfonation mixture to a water-miscible aliphatic alcohol, isolating the N-(2-sulfatoethyl)piperazine sulfate formed, treating the N-(2-sulfatoethyl)piperazine sulfate, still moist with alcohol, at temperatures of from about 35 DEG to about 90 DEG C. with a basic compound in a mixture of a (C1-C2)-alkanol and water, separating off the precipitated sulfate of the basic compound employed, and isolating the N-(2-sulfatoethyl)piperazine formed, by the addition of (C1-C2)-alkanol.