Receptor membranes
PCT No. PCT/AU88/00273 Sec. 371 Date Jan. 25, 1990 Sec. 102(e) Date Jan. 25, 1990 PCT Filed Jul. 27, 1988 PCT Pub. No. WO89/01159 PCT Pub. Date Feb. 9, 1989.The present invention provides a membrane comprising a closely packed array of self-assembly amphiphilic molecules, and is characterized in tha...
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| creator | CORNELL BRUCE A BRAACH-MAKSVYTIS VIJOLETA L. B |
| description | PCT No. PCT/AU88/00273 Sec. 371 Date Jan. 25, 1990 Sec. 102(e) Date Jan. 25, 1990 PCT Filed Jul. 27, 1988 PCT Pub. No. WO89/01159 PCT Pub. Date Feb. 9, 1989.The present invention provides a membrane comprising a closely packed array of self-assembly amphiphilic molecules, and is characterized in that it incorporates plurality of ion channels, and/or at least a proportion of the self-assembling molecules comprise a receptor molecule conjugated with a supporting entity. The ion channel is selected from the group consisting of peptides capable of forming helices and aggregates thereof, coronands, cryptands, podands and combinations thereof. In the amphiphilic molecules comprising a receptor molecule conjugated with a supporting entity, the receptor molecule has a receptor site and is selected from the group consisting of immunoglobulins, antibodies, antibody fragments, dyes, enzymes and lectins. The supporting entity is selected from the group consisting of a lipid head group, a hydrocarbon chain(s), a cross-linkable molecule and a membrane protein. The supporting entity is attached to the receptor molecule at an end remote from the receptor site. In preferred embodiments the ion channel is gramicidin A, and is preferably gated. Such membranes may be used in the formation of sensing devices. |
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Date Feb. 9, 1989.The present invention provides a membrane comprising a closely packed array of self-assembly amphiphilic molecules, and is characterized in that it incorporates plurality of ion channels, and/or at least a proportion of the self-assembling molecules comprise a receptor molecule conjugated with a supporting entity. The ion channel is selected from the group consisting of peptides capable of forming helices and aggregates thereof, coronands, cryptands, podands and combinations thereof. In the amphiphilic molecules comprising a receptor molecule conjugated with a supporting entity, the receptor molecule has a receptor site and is selected from the group consisting of immunoglobulins, antibodies, antibody fragments, dyes, enzymes and lectins. The supporting entity is selected from the group consisting of a lipid head group, a hydrocarbon chain(s), a cross-linkable molecule and a membrane protein. The supporting entity is attached to the receptor molecule at an end remote from the receptor site. In preferred embodiments the ion channel is gramicidin A, and is preferably gated. Such membranes may be used in the formation of sensing devices.</description><edition>6</edition><language>eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; COMPOSITIONS THEREOF ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; CULTURE MEDIA ; ENZYMOLOGY ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PERFORMING OPERATIONS ; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL ; PHYSICS ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SEPARATION ; SPIRITS ; TESTING ; TRANSPORTING ; VINEGAR ; WINE</subject><creationdate>1995</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19950725&DB=EPODOC&CC=US&NR=5436170A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19950725&DB=EPODOC&CC=US&NR=5436170A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CORNELL; BRUCE A</creatorcontrib><creatorcontrib>BRAACH-MAKSVYTIS; VIJOLETA L. B</creatorcontrib><title>Receptor membranes</title><description>PCT No. PCT/AU88/00273 Sec. 371 Date Jan. 25, 1990 Sec. 102(e) Date Jan. 25, 1990 PCT Filed Jul. 27, 1988 PCT Pub. No. WO89/01159 PCT Pub. Date Feb. 9, 1989.The present invention provides a membrane comprising a closely packed array of self-assembly amphiphilic molecules, and is characterized in that it incorporates plurality of ion channels, and/or at least a proportion of the self-assembling molecules comprise a receptor molecule conjugated with a supporting entity. The ion channel is selected from the group consisting of peptides capable of forming helices and aggregates thereof, coronands, cryptands, podands and combinations thereof. In the amphiphilic molecules comprising a receptor molecule conjugated with a supporting entity, the receptor molecule has a receptor site and is selected from the group consisting of immunoglobulins, antibodies, antibody fragments, dyes, enzymes and lectins. The supporting entity is selected from the group consisting of a lipid head group, a hydrocarbon chain(s), a cross-linkable molecule and a membrane protein. The supporting entity is attached to the receptor molecule at an end remote from the receptor site. In preferred embodiments the ion channel is gramicidin A, and is preferably gated. 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B</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CORNELL; BRUCE A</au><au>BRAACH-MAKSVYTIS; VIJOLETA L. B</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Receptor membranes</title><date>1995-07-25</date><risdate>1995</risdate><abstract>PCT No. PCT/AU88/00273 Sec. 371 Date Jan. 25, 1990 Sec. 102(e) Date Jan. 25, 1990 PCT Filed Jul. 27, 1988 PCT Pub. No. WO89/01159 PCT Pub. Date Feb. 9, 1989.The present invention provides a membrane comprising a closely packed array of self-assembly amphiphilic molecules, and is characterized in that it incorporates plurality of ion channels, and/or at least a proportion of the self-assembling molecules comprise a receptor molecule conjugated with a supporting entity. The ion channel is selected from the group consisting of peptides capable of forming helices and aggregates thereof, coronands, cryptands, podands and combinations thereof. In the amphiphilic molecules comprising a receptor molecule conjugated with a supporting entity, the receptor molecule has a receptor site and is selected from the group consisting of immunoglobulins, antibodies, antibody fragments, dyes, enzymes and lectins. The supporting entity is selected from the group consisting of a lipid head group, a hydrocarbon chain(s), a cross-linkable molecule and a membrane protein. The supporting entity is attached to the receptor molecule at an end remote from the receptor site. In preferred embodiments the ion channel is gramicidin A, and is preferably gated. Such membranes may be used in the formation of sensing devices.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SEPARATION SPIRITS TESTING TRANSPORTING VINEGAR WINE |
| title | Receptor membranes |
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