Platelet activating factor antagonists
PCT No. PCT/US92/01195 Sec. 371 Date Jul. 7, 1993 Sec. 102(e) Date Jul. 7, 1993 PCT Filed Feb. 14, 1992.Indole compounds substituted at the 1- or 3-position by a (pyrid-3-yl)thiazolid-4-yl)alkyl-, (pyrid-3-yl)thiazolid-4-oyl)-, (pyrid-3-yl)dithiolan-4-yl)alkyl- or (pyrid-3-yl)dithiolan-4-oyl)- group...
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| creator | HEYMAN H. ROBIN DAVIDSEN STEVEN K SHEPPARD GEORGE S PIREH DAISY MAY PAUL D STEINMAN DOUGLAS H SUMMERS JAMES B PHILLIPS JAMES G GUINN DENISE E CARRERA, JR. GEORGE M |
| description | PCT No. PCT/US92/01195 Sec. 371 Date Jul. 7, 1993 Sec. 102(e) Date Jul. 7, 1993 PCT Filed Feb. 14, 1992.Indole compounds substituted at the 1- or 3-position by a (pyrid-3-yl)thiazolid-4-yl)alkyl-, (pyrid-3-yl)thiazolid-4-oyl)-, (pyrid-3-yl)dithiolan-4-yl)alkyl- or (pyrid-3-yl)dithiolan-4-oyl)- group are potent inhibitors of PAF and are useful in the treatment of PAF-related disorders including septic shock, respiratory distress syndrome, acute inflammation, delayed cellular immunity, parturtition, fetal lung maturation, and cellular differentiation. |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Platelet activating factor antagonists |
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