Asymmetric hydrogenation of dihydro-pyrido [1,2-a]indoles
A process for the asymmetric hydrogenation of 6,7-dihydropyrido[1,2-a]indole-8-methanol or its aromatically-substituted derivatives of the formula II wherein R1, R2 and R3 each, independently, is hydrogen, halogen, C1-7-alkyl, C1-7-haloalkyl, hydroxy, C1-7-alkoxy, C1-7-alkylthio, C1-7-alkylsulfinyl,...
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| creator | BROGER EMIL A |
| description | A process for the asymmetric hydrogenation of 6,7-dihydropyrido[1,2-a]indole-8-methanol or its aromatically-substituted derivatives of the formula II wherein R1, R2 and R3 each, independently, is hydrogen, halogen, C1-7-alkyl, C1-7-haloalkyl, hydroxy, C1-7-alkoxy, C1-7-alkylthio, C1-7-alkylsulfinyl, C1-7-alkylsulfonyl, nitro, amino or acylamino, to (S)- or (R)-compounds of the formulanificances given above and the asterisk (*) denotes the chiral center, carried out using optically active rhodium-diphosphine complexes as catalysts, is described. The production of the compounds II, which also form an object of the invention, is also described. The compounds I and II are valuable intermediates, for example, for the preparation of pharmaceutically active substances. |
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The production of the compounds II, which also form an object of the invention, is also described. The compounds I and II are valuable intermediates, for example, for the preparation of pharmaceutically active substances.</description><edition>5</edition><language>eng</language><subject>APPARATUS THEREFOR ; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY ; CHEMISTRY ; GENERAL METHODS OF ORGANIC CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY ; PERFORMING OPERATIONS ; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL ; THEIR RELEVANT APPARATUS ; TRANSPORTING</subject><creationdate>1994</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19941220&DB=EPODOC&CC=US&NR=5374727A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19941220&DB=EPODOC&CC=US&NR=5374727A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BROGER; EMIL A</creatorcontrib><title>Asymmetric hydrogenation of dihydro-pyrido [1,2-a]indoles</title><description>A process for the asymmetric hydrogenation of 6,7-dihydropyrido[1,2-a]indole-8-methanol or its aromatically-substituted derivatives of the formula II wherein R1, R2 and R3 each, independently, is hydrogen, halogen, C1-7-alkyl, C1-7-haloalkyl, hydroxy, C1-7-alkoxy, C1-7-alkylthio, C1-7-alkylsulfinyl, C1-7-alkylsulfonyl, nitro, amino or acylamino, to (S)- or (R)-compounds of the formulanificances given above and the asterisk (*) denotes the chiral center, carried out using optically active rhodium-diphosphine complexes as catalysts, is described. The production of the compounds II, which also form an object of the invention, is also described. 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The production of the compounds II, which also form an object of the invention, is also described. The compounds I and II are valuable intermediates, for example, for the preparation of pharmaceutically active substances.</abstract><edition>5</edition><oa>free_for_read</oa></addata></record> |
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| subjects | APPARATUS THEREFOR CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL THEIR RELEVANT APPARATUS TRANSPORTING |
| title | Asymmetric hydrogenation of dihydro-pyrido [1,2-a]indoles |
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