Tetronic, thiotetronic and tetramic acid derivatives as phospholipase A2 inhibitors
There are disclosed compounds of the formula: wherein X is O, S or NR; R is hydrogen or lower alkyl; R1 and R2 are each, independently, hydrogen, C1-C10 alkyl, C3-C20 cycloalkyl, phenylloweralkyl, or substituted phenylloweralkyl substituted by halo, lower alkyl, lower alkoxy, halo lower alkyl, amino...
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| creator | CAUFIELD CRAIG E VONBURG GREGORY F SENKO NANCIE A SCHIEHSER GUY A |
| description | There are disclosed compounds of the formula: wherein X is O, S or NR; R is hydrogen or lower alkyl; R1 and R2 are each, independently, hydrogen, C1-C10 alkyl, C3-C20 cycloalkyl, phenylloweralkyl, or substituted phenylloweralkyl substituted by halo, lower alkyl, lower alkoxy, halo lower alkyl, amino, monoloweralkylamino, diloweralkylamino or sulfonamido; A is O, S, NR, or a chemical bond; m is 0-15; n is 0-20; p is 0-15, where m+p |
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| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_US5366993A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>US5366993A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_US5366993A3</originalsourceid><addsrcrecordid>eNqFyrEKwjAQxvEsDqI-g_cAdTFY6FjE4t46lzM5yUGbhNzR59dCd4ePPz_49qYfSEuK7CrQwEk3AUYPK3Be4diDp8ILKi8kgAI5JPlt4oxC0F6BY-A3aypyNLsPTkKnrQdz7h7D_XmhnEaSjI4i6fjqb7aum8a29v_jC6lPOCo</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Tetronic, thiotetronic and tetramic acid derivatives as phospholipase A2 inhibitors</title><source>esp@cenet</source><creator>CAUFIELD; CRAIG E ; VONBURG; GREGORY F ; SENKO; NANCIE A ; SCHIEHSER; GUY A</creator><creatorcontrib>CAUFIELD; CRAIG E ; VONBURG; GREGORY F ; SENKO; NANCIE A ; SCHIEHSER; GUY A</creatorcontrib><description>There are disclosed compounds of the formula: wherein X is O, S or NR; R is hydrogen or lower alkyl; R1 and R2 are each, independently, hydrogen, C1-C10 alkyl, C3-C20 cycloalkyl, phenylloweralkyl, or substituted phenylloweralkyl substituted by halo, lower alkyl, lower alkoxy, halo lower alkyl, amino, monoloweralkylamino, diloweralkylamino or sulfonamido; A is O, S, NR, or a chemical bond; m is 0-15; n is 0-20; p is 0-15, where m+p</=15; and the pharmacologically acceptable salts thereof, which by virtue of their ability to inhibit PLA2, are of use as antiinflammatory agents and there is also disclosed a method for the treatment of immunoinflammatory conditions, such as allergy, anaphylaxis, asthma and inflammation in mammals, as well as in the modulation of PAF-mediated biological processes, such as embryonic implantation, thus making the compounds useful as antifertility agents.
There are disclosed compounds of the formula: wherein X is O, S or NR; R is hydrogen or lower alkyl; R1 and R2 are each, independently, hydrogen, C1-C10 alkyl, C3-C20 cycloalkyl, phenylloweralkyl, or substituted phenylloweralkyl substituted by halo, lower alkyl, lower alkoxy, halo lower alkyl, amino, monoloweralkylamino, diloweralkylamino or sulfonamido; A is O, S, NR, or a chemical bond; m is 0-15; n is 0-20; p is 0-15, where m+p</=15; and the pharmacologically acceptable salts thereof, which by virtue of their ability to inhibit PLA2, are of use as antiinflammatory agents and there is also disclosed a method for the treatment of immunoinflammatory conditions, such as allergy, anaphylaxis, asthma and inflammation in mammals, as well as in the modulation of PAF-mediated biological processes, such as embryonic implantation, thus making the compounds useful as antifertility agents.</description><edition>5</edition><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>1994</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19941122&DB=EPODOC&CC=US&NR=5366993A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25569,76552</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19941122&DB=EPODOC&CC=US&NR=5366993A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CAUFIELD; CRAIG E</creatorcontrib><creatorcontrib>VONBURG; GREGORY F</creatorcontrib><creatorcontrib>SENKO; NANCIE A</creatorcontrib><creatorcontrib>SCHIEHSER; GUY A</creatorcontrib><title>Tetronic, thiotetronic and tetramic acid derivatives as phospholipase A2 inhibitors</title><description>There are disclosed compounds of the formula: wherein X is O, S or NR; R is hydrogen or lower alkyl; R1 and R2 are each, independently, hydrogen, C1-C10 alkyl, C3-C20 cycloalkyl, phenylloweralkyl, or substituted phenylloweralkyl substituted by halo, lower alkyl, lower alkoxy, halo lower alkyl, amino, monoloweralkylamino, diloweralkylamino or sulfonamido; A is O, S, NR, or a chemical bond; m is 0-15; n is 0-20; p is 0-15, where m+p</=15; and the pharmacologically acceptable salts thereof, which by virtue of their ability to inhibit PLA2, are of use as antiinflammatory agents and there is also disclosed a method for the treatment of immunoinflammatory conditions, such as allergy, anaphylaxis, asthma and inflammation in mammals, as well as in the modulation of PAF-mediated biological processes, such as embryonic implantation, thus making the compounds useful as antifertility agents.
There are disclosed compounds of the formula: wherein X is O, S or NR; R is hydrogen or lower alkyl; R1 and R2 are each, independently, hydrogen, C1-C10 alkyl, C3-C20 cycloalkyl, phenylloweralkyl, or substituted phenylloweralkyl substituted by halo, lower alkyl, lower alkoxy, halo lower alkyl, amino, monoloweralkylamino, diloweralkylamino or sulfonamido; A is O, S, NR, or a chemical bond; m is 0-15; n is 0-20; p is 0-15, where m+p</=15; and the pharmacologically acceptable salts thereof, which by virtue of their ability to inhibit PLA2, are of use as antiinflammatory agents and there is also disclosed a method for the treatment of immunoinflammatory conditions, such as allergy, anaphylaxis, asthma and inflammation in mammals, as well as in the modulation of PAF-mediated biological processes, such as embryonic implantation, thus making the compounds useful as antifertility agents.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1994</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqFyrEKwjAQxvEsDqI-g_cAdTFY6FjE4t46lzM5yUGbhNzR59dCd4ePPz_49qYfSEuK7CrQwEk3AUYPK3Be4diDp8ILKi8kgAI5JPlt4oxC0F6BY-A3aypyNLsPTkKnrQdz7h7D_XmhnEaSjI4i6fjqb7aum8a29v_jC6lPOCo</recordid><startdate>19941122</startdate><enddate>19941122</enddate><creator>CAUFIELD; CRAIG E</creator><creator>VONBURG; GREGORY F</creator><creator>SENKO; NANCIE A</creator><creator>SCHIEHSER; GUY A</creator><scope>EVB</scope></search><sort><creationdate>19941122</creationdate><title>Tetronic, thiotetronic and tetramic acid derivatives as phospholipase A2 inhibitors</title><author>CAUFIELD; CRAIG E ; VONBURG; GREGORY F ; SENKO; NANCIE A ; SCHIEHSER; GUY A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US5366993A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1994</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>CAUFIELD; CRAIG E</creatorcontrib><creatorcontrib>VONBURG; GREGORY F</creatorcontrib><creatorcontrib>SENKO; NANCIE A</creatorcontrib><creatorcontrib>SCHIEHSER; GUY A</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CAUFIELD; CRAIG E</au><au>VONBURG; GREGORY F</au><au>SENKO; NANCIE A</au><au>SCHIEHSER; GUY A</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Tetronic, thiotetronic and tetramic acid derivatives as phospholipase A2 inhibitors</title><date>1994-11-22</date><risdate>1994</risdate><abstract>There are disclosed compounds of the formula: wherein X is O, S or NR; R is hydrogen or lower alkyl; R1 and R2 are each, independently, hydrogen, C1-C10 alkyl, C3-C20 cycloalkyl, phenylloweralkyl, or substituted phenylloweralkyl substituted by halo, lower alkyl, lower alkoxy, halo lower alkyl, amino, monoloweralkylamino, diloweralkylamino or sulfonamido; A is O, S, NR, or a chemical bond; m is 0-15; n is 0-20; p is 0-15, where m+p</=15; and the pharmacologically acceptable salts thereof, which by virtue of their ability to inhibit PLA2, are of use as antiinflammatory agents and there is also disclosed a method for the treatment of immunoinflammatory conditions, such as allergy, anaphylaxis, asthma and inflammation in mammals, as well as in the modulation of PAF-mediated biological processes, such as embryonic implantation, thus making the compounds useful as antifertility agents.
There are disclosed compounds of the formula: wherein X is O, S or NR; R is hydrogen or lower alkyl; R1 and R2 are each, independently, hydrogen, C1-C10 alkyl, C3-C20 cycloalkyl, phenylloweralkyl, or substituted phenylloweralkyl substituted by halo, lower alkyl, lower alkoxy, halo lower alkyl, amino, monoloweralkylamino, diloweralkylamino or sulfonamido; A is O, S, NR, or a chemical bond; m is 0-15; n is 0-20; p is 0-15, where m+p</=15; and the pharmacologically acceptable salts thereof, which by virtue of their ability to inhibit PLA2, are of use as antiinflammatory agents and there is also disclosed a method for the treatment of immunoinflammatory conditions, such as allergy, anaphylaxis, asthma and inflammation in mammals, as well as in the modulation of PAF-mediated biological processes, such as embryonic implantation, thus making the compounds useful as antifertility agents.</abstract><edition>5</edition><oa>free_for_read</oa></addata></record> |
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| title | Tetronic, thiotetronic and tetramic acid derivatives as phospholipase A2 inhibitors |
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