Tetronic, thiotetronic and tetramic acid derivatives as phospholipase A2 inhibitors

Tetronic, thiotetronic and tetramic acid derivatives as phospholipase A2 inhibitors

There are disclosed compounds of the formula: wherein X is O, S or NR; R is hydrogen or lower alkyl; R1 and R2 are each, independently, hydrogen, C1-C10 alkyl, C3-C20 cycloalkyl, phenylloweralkyl, or substituted phenylloweralkyl substituted by halo, lower alkyl, lower alkoxy, halo lower alkyl, amino...

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Bibliographische Detailangaben
Hauptverfasser: CAUFIELD, CRAIG E, VONBURG, GREGORY F, SENKO, NANCIE A, SCHIEHSER, GUY A
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:There are disclosed compounds of the formula: wherein X is O, S or NR; R is hydrogen or lower alkyl; R1 and R2 are each, independently, hydrogen, C1-C10 alkyl, C3-C20 cycloalkyl, phenylloweralkyl, or substituted phenylloweralkyl substituted by halo, lower alkyl, lower alkoxy, halo lower alkyl, amino, monoloweralkylamino, diloweralkylamino or sulfonamido; A is O, S, NR, or a chemical bond; m is 0-15; n is 0-20; p is 0-15, where m+p