Radioisotope iodine-labeled 1 alpha (or 24R), 25-dihydroxy vitamin D3 derivatives
A novel 1 alpha (or 24R), 25-dihydroxy vitamin D3 amino acid derivative of the formula wherein R1 is OH or -O-CO-A-NH2, and R2 and R3 are each selected from the group consisting of hydrogen, OH and -O-CO-A-NH2; wherein one of R2 and R3 is hydrogen, one of R, R2 and R3 is OH, and one of R1, R2 and R3...
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| creator | TANABE MIYUKI IKUTA SHIGERU |
| description | A novel 1 alpha (or 24R), 25-dihydroxy vitamin D3 amino acid derivative of the formula wherein R1 is OH or -O-CO-A-NH2, and R2 and R3 are each selected from the group consisting of hydrogen, OH and -O-CO-A-NH2; wherein one of R2 and R3 is hydrogen, one of R, R2 and R3 is OH, and one of R1, R2 and R3 is -O-CO-A-NH2; and wherein A is C1-10 alkylene, is produced by removing a protective group for the amino group, e.g. 9-fluorenylmethyloxycarbonyl, in the presence of a base in an inert solvent. A radioisotope iodine-labeled residue is then attached to the amino group to produce a derivative useful in the assay of 1 alpha (or 24R), 25-dihydroxy vitamin D3 in a specimen. |
| format | Patent |
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A radioisotope iodine-labeled residue is then attached to the amino group to produce a derivative useful in the assay of 1 alpha (or 24R), 25-dihydroxy vitamin D3 in a specimen.</description><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS ; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC ; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS ; METALLURGY ; ORGANIC CHEMISTRY ; TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION ; TECHNICAL SUBJECTS COVERED BY FORMER USPC ; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS ; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE</subject><creationdate>1993</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19930525&DB=EPODOC&CC=US&NR=5214170A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19930525&DB=EPODOC&CC=US&NR=5214170A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>TANABE; MIYUKI</creatorcontrib><creatorcontrib>IKUTA; SHIGERU</creatorcontrib><title>Radioisotope iodine-labeled 1 alpha (or 24R), 25-dihydroxy vitamin D3 derivatives</title><description>A novel 1 alpha (or 24R), 25-dihydroxy vitamin D3 amino acid derivative of the formula wherein R1 is OH or -O-CO-A-NH2, and R2 and R3 are each selected from the group consisting of hydrogen, OH and -O-CO-A-NH2; wherein one of R2 and R3 is hydrogen, one of R, R2 and R3 is OH, and one of R1, R2 and R3 is -O-CO-A-NH2; and wherein A is C1-10 alkylene, is produced by removing a protective group for the amino group, e.g. 9-fluorenylmethyloxycarbonyl, in the presence of a base in an inert solvent. 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A radioisotope iodine-labeled residue is then attached to the amino group to produce a derivative useful in the assay of 1 alpha (or 24R), 25-dihydroxy vitamin D3 in a specimen.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS METALLURGY ORGANIC CHEMISTRY TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION TECHNICAL SUBJECTS COVERED BY FORMER USPC TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE |
| title | Radioisotope iodine-labeled 1 alpha (or 24R), 25-dihydroxy vitamin D3 derivatives |
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