MAMALIAN MONOCLONAL ANTIBODIES AGAINST ENDOTOXIN OF GRAM-NEGATIVE BACTERIA
Mammalian monoclonal anti-LPS antibodies that react with regions of lipopolysaccharide which are common to the lipopolysaccharide molecules of gram-negative bacteria of different genera are described along with diagnostic and therapeutic uses of the anti-LPS antibodies. The monoclonal anti-LPS antib...
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| creator | KUNG PATRICK C BOGARD, JR. WARREN C |
| description | Mammalian monoclonal anti-LPS antibodies that react with regions of lipopolysaccharide which are common to the lipopolysaccharide molecules of gram-negative bacteria of different genera are described along with diagnostic and therapeutic uses of the anti-LPS antibodies. The monoclonal anti-LPS antibodies react with gram-negative bacteria across different genera, reacting with regions of the lipid A and/or the core of gram-negative bacterial endotoxin which are shared by virtually all types of gram-negative bacteria. The anti-LPS antibodies protect mice against the lethal effect from gram-negative bacterial infection and neutralize the lethal effect of the endotoxin of gram-negative bacteria in vivo. Also disclosed are immortal antibody-producing cells such as mammalian hybridoma cell lines which generate the monoclonal anti-LPS antibodies. The mammalian monoclonal anti-LPS antibodies are useful in a number of diagnostic and therapeutic applications, including methods for the detection of gram-negative bacteria or endotoxin of gram-negative bacteria, therapy of gram-negative bacterial infection and endotoxin shock in mammals and prophylaxis against bacterial infection in mammals. |
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The monoclonal anti-LPS antibodies react with gram-negative bacteria across different genera, reacting with regions of the lipid A and/or the core of gram-negative bacterial endotoxin which are shared by virtually all types of gram-negative bacteria. The anti-LPS antibodies protect mice against the lethal effect from gram-negative bacterial infection and neutralize the lethal effect of the endotoxin of gram-negative bacteria in vivo. Also disclosed are immortal antibody-producing cells such as mammalian hybridoma cell lines which generate the monoclonal anti-LPS antibodies. The mammalian monoclonal anti-LPS antibodies are useful in a number of diagnostic and therapeutic applications, including methods for the detection of gram-negative bacteria or endotoxin of gram-negative bacteria, therapy of gram-negative bacterial infection and endotoxin shock in mammals and prophylaxis against bacterial infection in mammals.</description><language>eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; COMPOSITIONS THEREOF ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; CULTURE MEDIA ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; HUMAN NECESSITIES ; HYGIENE ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PHYSICS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; PROCESSES USING MICROORGANISMS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; TESTING ; VINEGAR ; WINE</subject><creationdate>1993</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19930112&DB=EPODOC&CC=US&NR=5179018A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19930112&DB=EPODOC&CC=US&NR=5179018A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KUNG; PATRICK C</creatorcontrib><creatorcontrib>BOGARD, JR.; WARREN C</creatorcontrib><title>MAMALIAN MONOCLONAL ANTIBODIES AGAINST ENDOTOXIN OF GRAM-NEGATIVE BACTERIA</title><description>Mammalian monoclonal anti-LPS antibodies that react with regions of lipopolysaccharide which are common to the lipopolysaccharide molecules of gram-negative bacteria of different genera are described along with diagnostic and therapeutic uses of the anti-LPS antibodies. The monoclonal anti-LPS antibodies react with gram-negative bacteria across different genera, reacting with regions of the lipid A and/or the core of gram-negative bacterial endotoxin which are shared by virtually all types of gram-negative bacteria. The anti-LPS antibodies protect mice against the lethal effect from gram-negative bacterial infection and neutralize the lethal effect of the endotoxin of gram-negative bacteria in vivo. Also disclosed are immortal antibody-producing cells such as mammalian hybridoma cell lines which generate the monoclonal anti-LPS antibodies. The mammalian monoclonal anti-LPS antibodies are useful in a number of diagnostic and therapeutic applications, including methods for the detection of gram-negative bacteria or endotoxin of gram-negative bacteria, therapy of gram-negative bacterial infection and endotoxin shock in mammals and prophylaxis against bacterial infection in mammals.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>COMPOSITIONS THEREOF</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PHYSICS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>PROCESSES USING MICROORGANISMS</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>TESTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1993</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqFyrEKwkAMANAuDqJ-g_mBgkVEHdNrekbuEuhFcStFzkm0UP8fF3ent7x5cY4YMTAKRBV1QQUDoBjX2jAlQI8syYCkUdMbC2gLvsNYCnk0vhLU6Iw6xmUxewzPKa9-Lop1S-ZOZR7ffZ7G4Z5f-dNf0q7aHzfVAbf_xxe2LizD</recordid><startdate>19930112</startdate><enddate>19930112</enddate><creator>KUNG; PATRICK C</creator><creator>BOGARD, JR.; WARREN C</creator><scope>EVB</scope></search><sort><creationdate>19930112</creationdate><title>MAMALIAN MONOCLONAL ANTIBODIES AGAINST ENDOTOXIN OF GRAM-NEGATIVE BACTERIA</title><author>KUNG; PATRICK C ; BOGARD, JR.; WARREN C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US5179018A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1993</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>COMPOSITIONS THEREOF</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PHYSICS</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>PROCESSES USING MICROORGANISMS</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>TESTING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>KUNG; PATRICK C</creatorcontrib><creatorcontrib>BOGARD, JR.; WARREN C</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KUNG; PATRICK C</au><au>BOGARD, JR.; WARREN C</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>MAMALIAN MONOCLONAL ANTIBODIES AGAINST ENDOTOXIN OF GRAM-NEGATIVE BACTERIA</title><date>1993-01-12</date><risdate>1993</risdate><abstract>Mammalian monoclonal anti-LPS antibodies that react with regions of lipopolysaccharide which are common to the lipopolysaccharide molecules of gram-negative bacteria of different genera are described along with diagnostic and therapeutic uses of the anti-LPS antibodies. The monoclonal anti-LPS antibodies react with gram-negative bacteria across different genera, reacting with regions of the lipid A and/or the core of gram-negative bacterial endotoxin which are shared by virtually all types of gram-negative bacteria. The anti-LPS antibodies protect mice against the lethal effect from gram-negative bacterial infection and neutralize the lethal effect of the endotoxin of gram-negative bacteria in vivo. Also disclosed are immortal antibody-producing cells such as mammalian hybridoma cell lines which generate the monoclonal anti-LPS antibodies. The mammalian monoclonal anti-LPS antibodies are useful in a number of diagnostic and therapeutic applications, including methods for the detection of gram-negative bacteria or endotoxin of gram-negative bacteria, therapy of gram-negative bacterial infection and endotoxin shock in mammals and prophylaxis against bacterial infection in mammals.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE |
| title | MAMALIAN MONOCLONAL ANTIBODIES AGAINST ENDOTOXIN OF GRAM-NEGATIVE BACTERIA |
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